System and method for quantitative dosimetry of photodynamic therapy in skin
AssigneeTrustees of Dartmouth College
InventorsAlberto J. Ruiz, Ethan P. M. Larochelle, Brian Pogue
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Abstract
While clinical treatment of actinic keratosis by photodynamic therapy (PDT) is widely practiced, there is well-known variability in response, primarily caused by heterogeneous accumulation and PDT-induced photobleaching of the photosensitizer protoporphyrin IX (PpIX) between patients and between lesions. One of the key factors in regularizing this treatment would be to have an easily accessible indicator of PpIX present in the lesions at the time of light delivery. Described herein, a smartphone-based fluorescence imager was developed to allow simple quantitative photography of the lesions and their PpIX levels.
Claims17
A fluorescence imaging apparatus, comprising:
- a housing including a first end, a second end, and an exit aperture disposed at the first end and optically connected to a window disposed at the second end, a mount disposed at the second end and configured to removeably couple a computing device to the housing such that an optical sensor of the computing device is aligned with the window, and an optical filter disposed in the window between the optical sensor and the exit aperture, the optical filter being removable from the window;
- a light ring disposed at the first end of the housing and mounted on a printed circuit board (PCB) having a metal core, the PCB being attached to the first end of the housing and configured to dissipate heat generated by the light ring, the light ring including a plurality of excitation light sources and a plurality of imaging light sources arranged on an outer portion of the light ring wherein one of the excitation light sources is arranged directly adjacent to one of the imaging light sources, the plurality of excitation light sources configured to emit light in a predetermined excitation wavelength range, the plurality of imaging light sources configured to emit light in a predetermined imaging wavelength range;
- and
- a cushioned ring removeably attached to the first end of the housing, contacting and surrounding the exit aperture, the cushioned ring configured to couple the first end of the housing to a surface of an object to block external light from an exterior of the cushioned ring, wherein
- the optical filter is configured to prevent transmission of electromagnetic radiation having a wavelength in the predetermined excitation wavelength range.
A method for fluorescent imaging using an imaging apparatus including a computing device, a housing, a light array ring, and a power source, the computing device including an optical sensor, a memory, and processing circuitry, the housing including a first end, a second end, an exit aperture disposed at the first end and optically connected to a window disposed at the second end, a mount disposed at the second end and configured to removeably couple the computing device to the housing such that the optical sensor is aligned with the window, and an optical filter disposed in the window between the optical sensor and the exit aperture, the optical filter being removable from the window, the light ring disposed at the first end of the housing and mounted on a printed circuit board (PCB) having a metal core, the PCB being attached to the first end of the housing and configured to dissipate heat generated by the light ring, the light ring including a plurality of excitation light sources and a plurality of imaging light sources arranged on an outer portion of the light ring, wherein one of the excitation light sources is arranged directly adjacent to one of the imaging light sources, the plurality of excitation light sources configured to emit light in a predetermined excitation wavelength range, the plurality of imaging light sources configured to emit light in a predetermined imaging wavelength range, and a cushioned ring removeably attached to the first end of the housing, contacting and surrounding the exit aperture, the cushioned ring configured to couple the first end of the housing to a surface of an object to block external prevent light from an exterior of the cushioned ring, the method comprising:
- arranging the imaging apparatus so as to press against the object such that the light from the exterior is prevented from entering the interior of the cushion;
- receiving, via the optical sensor, an image;
- storing the image in the memory;
- and
- determining, via the processing circuitry, an intensity value for each of a plurality of pixels in the image.
Dependencies are inferred from the claim text.