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US 12,496,376 B2Granted
Tissue repair laminates
AssigneePolynovo Biomaterials Pty Limited
InventorTimothy Graeme Moore
Life of this patent
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Abstract
There are provided tissue repair laminates which promote cellular in-growth but also prevent or mitigate tissue adhesion. The laminates comprise a biodegradable polyurethane foam layer which facilitates cellular infiltration and a polyurethane barrier layer which is non-adhesive to tissue. The laminates resist shrinkage under in vivo conditions and possess desirable mechanical properties. The laminates find use in, for example, the repair of herniated tissue, particularly, but not limited to hernias in the abdominal wall.
Claims21
A tissue repair laminate comprising:
- (a) a biodegradable polyurethane foam layer having first and second oppositely facing major surfaces;
- and
- (b) a biodegradable polyurethane barrier layer having first and second oppositely facing major surfaces;
- wherein the first major surface of said barrier layer and the second major surface of said foam layer face each other;
- wherein said foam layer comprises a pore structure configured for cellular infiltration;
- wherein the second major surface of said barrier layer is less adhesiogenic than the first major surface of said foam layer;
- and
- wherein the average pore size of the foam layer is greater than 75 μm.
5 more elements
Dependencies are inferred from the claim text.