Imaging compounds for detecting or imaging senescent cells
AssigneeUniversity of Dundee
InventorsVassilis G. Gorgoulis, Nikolaos Lougiakis, Panagiotis Marakos, Nicole Pouli, Athanassios Kotsinas, Konstantinos Evangelou, Russell Petty, Ilias Christos Tzortzatos
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Abstract
A compound, or a salt or solvate thereof, according to formula I as defined herein and pharmaceutical composition comprising said compound. Compounds of formula I are capable of detecting senescence. As such, these compounds are useful in methods of detecting or imaging senescent cells or extracts thereof or senescence in a subject or a biological sample taken from a subject.
Claims19
A compound, or a salt or solvate thereof, according to formula I:
- T-L-D (I)
- wherein
- wherein:
- R10 and R14 are independently selected from hydrogen and methoxy;
- R17 and R18 are each independently C1-4alkyl;
- and
- X⊖ is a counterion;
- L is a linking moiety of formula VII:
- -[L2]-[L3]-[L4]-[L10]-[L11]- (VII),
- wherein:
- L2 is —O—, —C(═O)—, —C(═O)O—, —OC(═O)—, or —(CR5R6)p—;
- L3 is absent or —(CR5R6)p—;
- L4 is absent, —C(═O)—, —C(═O)NR5—, —C(═O)O—, or —(CR5R6)p—;
- L10 is (CH2);
- L11 is —NH—;
- R5 and R6, at each occurrence, are independently selected from hydrogen, methyl and ethyl;
- p is an integer from 1 to 6;
- and
- T is a lipid-targeting moiety of formula T1:
A compound selected from the group consisting of:
- or a salt or solvate thereof.
A compound which is:
- or a salt or a solvate thereof.
Dependencies are inferred from the claim text.