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US 12,496,343 B2Granted
Long-acting photoreceptor-binding nanoparticles, and compositions and methods thereof
AssigneeThe University of Masachusetts
InventorsGang Han, Tian Xue
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Abstract
The invention provides a novel class of long-acting photoreceptor-binding nanoparticles, methods of their preparation, and compositions and uses thereof. The invention also relates to use of such nanoparticles and compositions for NIR light sensation and pattern vision, visual enhancement and repair, and other ophthalmology therapies.
Claims11
A nanoassembly comprising:
- an upconversion nanoparticle (UCNP) sized between 28 nm and 48 nm having a core/shell structure;
- and
- concanavalin A protein (ConA) covalently attached to the UCNP,
- wherein the UCNP
- comprises β-NaYF4:Yb and Er@ β-NaYF4, wherein Yb is present at about 5% to about 99.5% and Er is present at about 0.1% to about 95%, and
- is capable of converting a near infrared (NIR) light having a wavelength in the range of about 700 nm to about 1,700 nm to a wavelength in the visible region of about 400 nm to about 700 nm,
- wherein
- the UCNP is oxidized with nitrosonium tetrafluoroborate and coated with polyacrylic acid, and
- the ConA is covalently coupled to the polyacrylic acid coated on the UCNP.
6 more elements
A mammal-device interface comprising:
- an upconversion nanoparticle (UCNP) sized between 28 nm and 48 nm having a core/shell structure;
- and
- concanavalin A protein (ConA) covalently attached to the UCNP,
- wherein the UCNP comprises β-NaYF4:Yb and Er@β-NaYF4, wherein Yb is present at about 5% to about 99.5% and Er is present at about 0.1% to about 95%, and
- is capable of converting a near infrared (NIR) light having a wavelength in the range of about 700 nm to about 1,700 nm to a wavelength in the visible region of about 400 nm to about 700 nm,
- wherein
- the UCNP is oxidized with nitrosonium tetrafluoroborate and coated with polyacrylic acid, and
- the ConA is covalently coupled to the polyacrylic acid coated on the UCNP.
5 more elements
Dependencies are inferred from the claim text.