Peptide vaccine based on a new universal influenza a hemagglutinin head domain epitope and human monoclonal antibodies binding thereto
AssigneesVanderbilt University, The Scripps Research Institute
InventorsJames E. Crowe, Jr., Xiaozhen Hu, William Schief
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Abstract
The present disclosure is directed to peptide antigens derived from a previously undefined epitope on influenza A virus hemagglutinin and methods for use thereof.
Claims27
A method of inducing an immune response in a subject infected with influenza A virus or at risk of contracting influenza A virus, comprising delivering to said subject one or more immunogen(s), or one or more RNA(s) or expression vector(s) encoding said immunogen(s), wherein said immunogen(s) is/are selected from peptide(s) SEQ ID NOS:
- 11-22, 24, 29, and/or 30, or are selected from peptide(s) comprising 95% identity to peptide(s) comprising SEQ ID NOS:
- 1-10, 23, 25-28, 31 and/or 32.
A vaccine formulation comprising one or more immunogen(s), or one or more RNA(s) or expression vector(s) encoding said peptide(s), wherein said immunogen(s) is/are selected from peptide(s) SEQ ID NOS:
- 11-22, 24, 29, and/or 30, or are selected from peptide(s) comprising 95% identity to peptide(s) comprising SEQ ID NOS:
- 1-10, 23, 25-28, 31 and/or 32.
Dependencies are inferred from the claim text.