US 12,496,321 B2 · Anti-fatigue Lactobacillus composition and method of promoting anti-fatigue performance after aerobic exercise of subject in need thereof by using the same

Abstract

The present disclosure relates to an anti-fatigue Lactobacillus composition. The anti-fatigue Lactobacillus composition, which includes at least one of Lactobacillus brevis GKEX, Lactobacillus plantarum GKK1 and Lactobacillus johnsonii GKJ2 as an active ingredient, administered to a healthy subject for a continuous period of time, can significantly improve fatigue-related biochemical indices and prolong aerobic exercise time to exhaustion, and thus can be used as an active ingredient for preparation of various compositions for anti-fatigue and/or improving athletic ability.

Claims12

Dependent claims

A method of promoting anti-fatigue performance after aerobic exercise in a subject in need thereof, comprising:

orally administering an anti-fatigue Lactobacillus composition to a healthy subject for at least four consecutive weeks, wherein the anti-fatigue Lactobacillus composition consists of:
an effective dose of a Lactobacillus species selected from the group consisting of Lactobacillus brevis strain GKEX deposited at International Patent Organisms Depositary (IPOD) under International Accession Number NITE BP-03696, Lactobacillus johnsonii strain GKJ2 deposited at IPOD under International Accession Number NITE BP-03315, and any combination thereof;
wherein the anti-fatigue performance comprises;
prolonging swimming time to exhaustion, prolonging running time to exhaustion, reducing an elevated ratio of serum lactate, reducing an elevated serum urea nitrogen concentration, and/or increasing liver glycogen content after the aerobic exercise.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

18/756,561Filed 27 Jun 2024 · division

Priority

TW 11211370212 Apr 2023

Published

US 2024/0342229 A117 Oct 2024

Granted

16 Dec 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

A61K 35/747
Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs: lactobacilli, e.g. L. acidophilus or L. brevis
A23L 33/135
Using additives: bacteria or derivatives thereof, e.g. probiotics
A61K 9/0053
Galenical forms characterised by the site of application: mouth and digestive tract, i.e. intraoral and peroral administration
A61K 9/19
Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles: lyophilised , i.e.…

Anti-fatigue Lactobacillus composition and method of promoting anti-fatigue performance after aerobic exercise of subject in need thereof by using the same

Life of this patent

Anti-fatigue Lactobacillus composition and method of promoting anti-fatigue performance after aerobic exercise of subject in need thereof by using the same

Life of this patent

Abstract

Claims12