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US 12,496,318 B2Granted
Methods for treating a health condition with probiotics
OwnerSabine Hazaninventor
Life of this patent
Estimating the term…
Abstract
Methods of treating a health condition by standardizing patients and donors with pre-treatment protocols to enhance the effects of probiotic administration, improving preservation steps of samples handled, and selecting best matching donors for selection for probiotic administration to effectively treat the health condition.
Claims22
A method of treating a patient with a disease, the method comprising the steps of:
- a) screening an individual to determine whether the individual has the disease, wherein if the individual has the disease, the individual is the patient;
- b) acquiring a baseline fecal sample from the patient prior to acquiring the disease, wherein the baseline fecal sample contains a microbiome of the patient prior to acquiring the disease;
- c) processing the baseline fecal sample from the patient prior to acquiring the disease by extracting and purifying DNA from the baseline fecal sample of the patient and preparing a DNA library of the microbiome of the patient;
- d) preparing a plurality of donors for the fecal microbiota transplant by directing discontinuation of any existing antibiotic treatment;
- e) acquiring fecal samples from the plurality of donors, wherein the fecal samples of the plurality of donors contain a microbiome of the respective donor;
- f) processing the fecal samples from the plurality of donors to by extracting and purifying DNA from the fecal samples of the donor and preparing a separate DNA library of the microbiomes of each donor;
- g) comparing the DNA library from the baseline fecal sample of the patient to the DNA library of each donor to determine a matching donor having a DNA library containing a type and amount of bacteria that is more similar to the DNA library of the patient as compared to the DNA library of other donors in the plurality of donors;
- and
- h) after determining the matching donor, administering rectally into the patient a probiotic derived from the matching donor, wherein the probiotic treats the disease of the patient.
6 more elements
A method of treating a patient with a disease, the method comprising the steps of:
- a) screening an individual to determine whether the individual has the disease, wherein if the individual has the disease, the individual is the patient;
- b) preparing the patient for a probiotic administration by directing discontinuation of any existing antibiotic treatment;
- c) acquiring a baseline fecal sample from the patient prior to acquiring the disease, wherein the baseline fecal sample contains a microbiome of the patient;
- d) processing the baseline fecal sample from the patient prior to acquiring the disease by extracting and purifying DNA from the fecal sample of the patient prior to acquiring the disease and preparing a DNA library of the microbiome of the patient;
- e) preparing a plurality of donors for the probiotic administration by directing discontinuation of any existing antibiotic treatment;
- f) acquiring fecal samples from the plurality of donors, wherein the fecal samples of the plurality of donors contain a microbiome of the respective donor;
- g) processing the fecal samples from the plurality of donors by extracting and purifying DNA from the fecal samples of the donor and preparing a separate DNA library of the microbiomes of each donor;
- h) comparing the DNA library from the baseline fecal sample of the patient to the DNA library of each donor to determine a matching donor having a DNA library containing a type and amount of bacteria that is more similar to the DNA library of the baseline fecal sample of the patient as compared to the DNA library of other donors in the plurality of donors;
- and
- i) after determining the matching donor, administering a probiotic derived from the matching donor, wherein the probiotic treats the disease of the patient.
7 more elements
Dependencies are inferred from the claim text.