Use of itaconate and its derivatives/analogues to induce hair growth
AssigneeThe Johns Hopkins University
InventorsLuis Garza, Mohameed Islam, Barbara Slusher, Rana Rais
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Abstract
Methods for the use of prodrugs of itaconic acid and 1- and 4-methyl itaconic acid for inducing hair growth and treating an inflammatory, or immune activation (adaptive or innate), skin condition or other condition associated with hair loss are disclosed.
Claims16
A method for inducing hair growth or treating a hair loss condition in a subject, the method comprising administering to the subject a therapeutically effective amount of a compound of formula (I):
- wherein:
- R1 is
- wherein n is an integer selected from 1, 2, 3, and 4;
- R4 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl or —OR5, wherein R5 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl;
- and
- R2 is —OR3, wherein R3 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl.
A method for inducing hair growth or treating a hair loss condition in a subject, the method comprising administering to the subject a therapeutically effective amount of a compound having the structure:
A method for inducing hair growth or treating a hair loss condition in a subject, the method comprising administering to the subject a therapeutically effective amount of a compound having the structure:
A method for inducing hair growth or treating a hair loss condition in a subject, the method comprising administering to the subject a therapeutically effective amount of a compound having the structure:
Dependencies are inferred from the claim text.