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US 12,496,280 B2Granted
Pharmaceutical ophthalmic compositions for protection against blue light
AssigneeSophia Holdings, S.A. De C.V.
InventorsPaulina Chávez Hurtado, Juan Manuel Martinez Alejo, Juan de Dios Quintana Hau
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Abstract
The present invention relates to ophthalmic pharmaceutical compositions in the form of oil-in-water (O/W) nanoemulsions comprising a mixture of specific components with modified physicochemical properties, in combination with an oil-xantophyll mixture for protection against blue light.
Claims8
An ophthalmic pharmaceutical composition in the form of an oil-in-water (O/W) emulsion comprising lipid particles;
- characterized in that it comprises:
- a) at least one mixture comprising a xanthophyll and an ophthalmic acceptable oil;
- b) at least one organic polyol compound;
- c) at least one polymer that has been fully or partially mechanically fragmented;
- d) at least one phospholipid;
- and
- e) at least one pharmaceutically acceptable excipient,
- wherein the lipid particles of the O/W emulsion have a net negative charge of less than −20 mV;
- and
- wherein when the ophthalmic pharmaceutical composition is applied to the eye of a subject it is maintained on the ocular surface and functions as a blue light filter.
7 more elements
Dependencies are inferred from the claim text.