Kirigami-inspired stents for sustained local delivery of therapeutics
AssigneesMassachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
InventorsSahab Babaee, Yichao Shi, Saeed Abbasalizadeh, Robert Langer, Carlo Traverso
Life of this patent
Estimating the term…
Abstract
The present disclosure provides a kirigami-inspired injectable stent system. The stent systems and methods enable radial/circumferential and longitudinal delivery of an extended release of therapeutics within tubular structures of the body, such as the GI tract and trachea. According to some aspects, a kirigami-based injectable stent system is provided that can enable drug release through deposition of therapeutic-coated needles of the stent in the tubular mucosa, such as often found in the gastrointestinal tract or trachea.
Claims12
A stent system for treating a submucosal tissue of a subject, the system comprising:
- a tubular body extending along a central axis to form a lumen within the tubular body including two cutouts each coupled to a first end and a second end of the tubular body and configured as a first and second endcap of the tubular body,
- an actuator integrated within the lumen and configured to move the tubular body between a retracted position and an elongated position, wherein the tubular body encloses the actuator via the first and second endcaps;
- and
- a pattern of a plurality of cuts formed along the tubular body and extending through the tubular body to the lumen,
- wherein the pattern of the plurality of cuts deploy into a plurality of interconnected projections that are configured to extend radially away from the tubular body relative to the central axis to engage a submucosal tissue within the gastrointestinal tract or trachea of a subject when the tubular body is moved towards the elongated position.
A method of inserting a stent into a gastrointestinal tract or trachea a subject, the method comprising:
- positioning a stent to a target tissue site within a gastrointestinal tract or trachea, the stent having a tubular body extending along a central axis to form a lumen within the tubular body including two cutouts each coupled to a first end and a second end of the tubular body and configured as a first and second endcap of the tubular body,
- pressurizing an actuator integrated within the lumen and to move the tubular body from a retracted position to an elongated position, wherein the tubular body encloses the actuator via the first and second endcaps,
- wherein a surface of the tubular body includes a pattern of a plurality of cuts configured to deploy into a plurality of interconnected projections as the tubular body is moved into the elongated position to engage the target tissue site of the subject.
Dependencies are inferred from the claim text.