Mediation of in vivo analyte signal degradation
AssigneeSenseonics, Incorporated
InventorsJoon Chatterjee, Sanat Mohanty, Philip Huffstetler, Venkata Velvadapu, Leopoldo Torres, Jr.
Life of this patent
Estimating the term…
Abstract
A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more compounds containing boronate or boronic acid moieties that reduce degradation of the analyte indicator.
Claims25
A sensor for measurement of an analyte in a medium within a living animal, the sensor comprising:
- a sensor housing;
- an analyte indicator covering at least a portion of the sensor housing;
- and
- one or more compounds containing boronate or boronic acid moieties that reduce degradation of the analyte indicator, wherein the one or more compounds containing boronic acid containing moieties are a compound of Formula I:
- wherein R=methylene or an alkyl group, an aryl group, a heteroaryl group, a cyclic group, a multicyclic group, a polyalkylene glycol group, a polyethylene glycol (PEG) group, a linear or substituted polyalkylene glycol or PEG group, or a combination thereof, or a compound of Formula I wherein the boronic acid is substituted with a boronate group of Formula II:
- wherein X and Y=alkyl.
A method of fabricating a sensor for measurement of an analyte in a medium within a living animal, the method comprising:
- applying an analyte indicator to a sensor housing of the sensor such that the applied analyte indicator covers at least a portion of the sensor housing, wherein the analyte indicator comprises one or more compounds containing boronate or boronic acid moieties that reduce degradation of the analyte indicator, wherein the one or more compounds containing boronic acid containing moieties are a compound of Formula I:
- wherein R=methylene or an alkyl group, an aryl group, a heteroaryl group, a cyclic group, a multicyclic group, a polyalkylene glycol group, a polyethylene glycol (PEG) group, a linear or substituted polyalkylene glycol or PEG group, or a combination thereof, or a compound of Formula I wherein the boronic acid is substituted with a boronate group of Formula II:
- wherein X and Y=alkyl.
Dependencies are inferred from the claim text.