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US 12,495,983 B2Granted
Perfusion measurement with low field NMR
AssigneeWellumio Limited
InventorsSergei Obruchkov, Alice Little
Life of this patent
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Abstract
The present disclosure relates to the field of medical applications. In particular, to a measurement system and method for non-invasive detection and monitoring of physiological parameters, in particular perfusion, to provide clinically relevant information through Nuclear Magnetic Resonance (NMR) observation.
Claims20
A low field Nuclear Magnetic Resonance (NMR) perfusion measurement system comprising:
- a magnetic structure configured to receive a body part of an examined subject and to create an inhomogeneous static magnetic field within a test tissue of the examined subject;
- wherein the static magnetic field provides a gradient in the test tissue, and is functioning without gradient coils;
- means to apply a first inversion recovery radiofrequency (RF) pulse sequence and a second inversion recovery RF pulse sequence to the test tissue, wherein an inversion pulse of the first or second pulse sequences has a different bandwidth and inverts a different volume than a corresponding inversion pulse of the other of the first or second pulse sequence;
- wherein the volume inverted by the first and second inversion pulse sequences depend on the different bandwidths;
- and
- acquisition means to acquire magnetic resonance signal data from the first and second inversion recovery pulse sequences and process the magnetic resonance signal data to provide perfusion data.
3 more elements
A method for measuring perfusion comprising:
- applying an inhomogeneous static magnetic field to a test tissue of an examined subject with a low field NMR:
- wherein the static magnetic field provides a gradient in the test tissue, and is functioning without gradient coils;
- applying a first inversion recovery RF pulse sequence and a second inversion recovery RF pulse sequence to the test tissue, wherein an inversion pulse of the first sequence has a different bandwidth and inverts a different volume than the inversion pulse of the second pulse sequence and wherein the volume inverted by the first and second inversion pulse sequences depend on the different bandwidths;
- acquiring magnetic resonance signal data from the first and second pulse sequences and processing the magnetic resonance signal data to provide perfusion data.
1 more element
Dependencies are inferred from the claim text.