Compositions and methods for induced tissue regeneration in mammalian species
AssigneeReverse BioEngineering, Inc.
InventorsMichael D. West, Karen Chapman, Hal Sternberg
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Abstract
Aspects of the present invention include methods and compositions related to the modulation of molecules regulating the regenerative potential of cells and tissues in the embryonic state and the loss thereof in later fetal and adult stages of development. The methods and compositions have uses in research in stem cell biology and in increasing regenerative potential in fetal and adult tissues otherwise incapable of regeneration.
Claims17
A method of increasing regenerative potential of mammalian connective tissue ex vivo or in vitro comprising administering to the cells of the tissue a composition comprising a de-differentiation gene of OXTR and one or more de-differentiation genes selected from the group consisting of SOX2, KLF4, OCT4, MYC, NANOG, and LIN28, wherein one or more viral vectors comprise the one or more de-differentiation genes.
A kit for enhancing regenerative potential of mammalian connective tissue wherein the kit comprises one or more de-differentiation genes of OXTR and one or more genes selected from the group consisting of SOX2, KLF4, OCT4, MYC, NANOG, and LIN28, wherein one or more viral vectors comprise the one or more genes.
Dependencies are inferred from the claim text.