suPAR and prediction and treatment of acute kidney injury
AssigneesEmory University, Rush University Medical Center
InventorsJochen Reiser, Salim Hayek, Arshed A. Quyyumi
Life of this patent
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Abstract
Methods and compositions for treating acute kidney injury in a subject are provided. The methods include measuring or having measured a level of soluble urokinase plasminogen activator receptor (suPAR) in a biological sample from the subject, determining or having determined the level of suPAR in the sample compared to a control suPAR level, and administering a therapeutically effective amount of an agent that antagonizes soluble urokinase plasminogen activator receptor (suPAR) to the subject having an elevated level of suPAR relative to the control suPAR level.
Claims9
A method of treating or reducing the incidence or severity of acute kidney injury induced by a contrast agent in a human patient, the method comprising:
- measuring or having measured a level of soluble urokinase plasminogen activator receptor (suPAR) in a biological sample from the human patient exposed to a contrast agent;
- determining or having determined the level of suPAR in the sample is a suPAR level of about 3 ng/ml or greater;
- and
- administering a therapeutically effective amount of an anti-suPAR antibody or antigen-binding fragment thereof that specifically binds to suPAR to the human patient thereby reducing the incidence or severity of acute kidney injury induced by the contrast agent.
Dependencies are inferred from the claim text.