Neutralizing anti-influenza A antibodies and uses thereof
AssigneesMedImmune, LLC, Humabs Biomed SA
InventorsEbony Benjamin, Nicole Kallewaard-Lelay, Josephine Mary McAuliffe, Frances Palmer-Hill, Leslie Wachter, Andy Yuan, Qing Zhu, Davide Corti, Antonio Lanzavecchia, Barbara Guarino, Anna DeMarco
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Abstract
The invention relates to antibodies and binding fragments thereof that are capable of binding to influenza A virus hemagglutinin and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus.
Claims16
A method for prophylaxis or treatment of Influenza A infection in a subject comprising administering to the subject an effective amount of an isolated antibody or binding fragment thereof that is capable of binding to influenza A virus hemagglutinin and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus, wherein the antibody or fragment thereof comprises a VH of SEQ ID NO.:
- 102 and a VL of SEQ ID NO.:
- 107.
A method for prophylaxis or treatment of Influenza A infection in a subject comprising administering to the subject an effective amount of an isolated antibody or binding fragment thereof that is capable of binding to influenza A virus hemagglutinin and neutralizing at least one group 1 subtype and at least 1 group 2 subtype of influenza A virus, wherein the antibody or fragment thereof comprises a VH of SEQ ID NO.:
- 102 and a VL of SEQ ID NO.:
- 107, in combination with a small molecule antiviral composition.
Dependencies are inferred from the claim text.