Pyrazole derivatives for the treatment of cystic fibrosis

A method of treating cystic fibrosis, the method comprising administering an effective amount of a compound or a pharmaceutically acceptable salt of the compound or solvate of the compound to a subject in need thereof,

• wherein the compound is selected from the group consisting of:
• #
• Substance Name
• 4
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(2,3-dihydro-1,4-
• benzodioxin-6-yl)-N-ethyl-benzamide,
• 7
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-methyl-N-phenyl-
• benzamide,
• 8
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-methyl-N-(2,2,3,3-
• tetrafluoro-1,4-benzodioxin-6-yl)benzamide,
• 9
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(2,2-difluoro-1,3-
• benzodioxol-5-yl)-N-methyl-benzamide
• 10
• N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-methyl-3-pyrazol-1-yl-
• benzamide,
• 11
• N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(3,5-dimethylpyrazol-
• 1-yl)-N-methyl-benzamide,
• 14
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(3,4-dimethoxyphenyl)-
• N-methyl-benzamide,
• 15
• N-(1,3-benzodioxol-5-yl)-3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-
• N-methyl-benzamide,
• 17
• N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(3,5-dimethylpyrazol-1-
• yl)-N-methyl-benzenesulfonamide,
• 19
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(2,2-difluoro-1,3-
• benzodioxol-5-yl)-N-ethyl-benzamide,
• 20
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(2,3-dihydro-1,4-
• benzodioxin-6-yl)-N-methyl-benzenesulfonamide,
• 23
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-indan-5-yl-N-methyl-
• benzamide,
• 24
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-methyl-N-(1-
• methylbenzimidazol-5-yl)benzamide,
• 25
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-methyl-N-(2-methyl-
• 1,3-benzoxazol-5-yl)benzamide,
• 29
• N-(1,3-benzoxazol-5-yl)-3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-
• N-methyl-benzamide,
• 31
• 5-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(2,3-dihydro-1,4-
• benzodioxin-6-yl)-N,2-dimethyl-benzamide,
• 32
• N-(6-chloro-2,3-dihydro-1,4-benzodioxin-7-yl)-3-(4-chloro-3,5-
• dimethyl-pyrazol-1-yl)-N-methyl-benzamide,
• 33
• 3-(4-chloropyrazol-1-yl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-
• N-methyl-benzamide,
• 34
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(2,2-dimethyl-1,3-
• benzodioxol-5-yl)-N-methyl-benzamide,
• 35
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(2,2-difluoro-1,3-
• benzodioxol-5-yl)-N-methyl-benzenesulfonamide,
• 36
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(3,4-dihydro-2H-1,4-
• benzoxazin-7-yl)-N-methyl-benzamide;
• 2,2,2-trifluoroacetic acid,
• 37
• 3-(4-tert-butyl-3,5-dimethyl-pyrazol-1-yl)-N-(2,3-dihydro-1,4-
• benzodioxin-6-yl)-N-methyl-benzamide,
• 38
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(3,4-dihydro-2H-1,4-
• benzoxazin-6-yl)-N-methyl-benzamide;
• 2,2,2-trifluoroacetic acid,
• 42
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-methyl-N-(6-methyl-
• 1,3-benzodioxol-5-yl)benzamide,
• 43
• ethyl 1-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl] phenyl]-
• 3,5-dimethyl-pyrazole-4-carboxylate,
• 44
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-methyl-N-tetralin-
• 6-yl-benzamide,
• 47
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-methyl-N-(2-methyl-
• 1,3-benzoxazol-6-yl)benzamide,
• 48
• 1-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-3,5-
• dimethyl-pyrazole-4-carboxylic acid,
• 49
• N-(6-chloro-2,2-difluoro-1,3-benzodioxol-5-yl)-3-(4-chloro-3,5-
• dimethyl-pyrazol-1-yl)-N-methyl-benzamide,
• 55
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(2-cyclopropyl-1,3-
• benzoxazol-5-yl)-N-methyl-benzamide,
• 56
• 1-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-3,5-
• dimethyl-pyrazole-4-carboxamide,
• 57
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(1,3-
• dihydroisobenzofuran-5-yl)-N-methyl-benzamide,
• 58
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(2,3-
• dihydrobenzofuran-5-yl)-N-methyl-benzamide,
• 59
• 1-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-N-(2-
• hydroxyethyl)-3,5-dimethyl-pyrazole-4-carboxamide,
• 62
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(2-isopropyl-1,3-
• benzoxazol-5-yl)-N-methyl-benzamide,
• 64
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(2-methoxy-1,3-
• benzoxazol-5-yl)-N-methyl-benzamide,
• 65
• 2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-5-
• methyl-pyrazole-3-carboxylic acid,
• 66
• 1-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-5-
• methyl-pyrazole-3-carboxylic acid,
• 67
• ethyl 1-[3-[1,3-benzodioxol-5-yl(methyl) carbamoyl]phenyl]-4-
• chloro-5-methyl-pyrazole-3-carboxylate,
• 68
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(3-methoxyphenyl)-
• N-methyl-benzamide,
• 69
• 1-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-4-chloro-
• 5-methyl-pyrazole-3-carboxylic acid,
• 70
• N-(1,3-benzodioxol-5-yl)-3-[5-(hydroxymethyl)-3-methyl-
• pyrazol-1-yl]-N-methyl-benzamide,
• 71
• N-(1,3-benzodioxol-5-yl)-3-(4-chloro-3,5-dimethyl-pyrazol-1-
• yl)-N-methyl-4-(trifluoromethyl)benzamide,
• 72
• N-(1,3-benzodioxol-5-yl)-2-(4-chloro-3,5-dimethyl-pyrazol-1-
• yl)-N-methyl-pyrimidine-4-carboxamide,
• 73
• N-(1,3-benzodioxol-5-yl)-3-[4-chloro-3-(hydroxymethyl)-5-
• methyl-pyrazol-1-yl]-N-methyl-benzamide,
• 74
• 1-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-4-chloro-
• 5-methyl-pyrazole-3-carboxamide,
• 75
• ethyl 2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-4-
• chloro-5-methyl-pyrazole-3-carboxylate,
• 76
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(2-ethyl-1,3-benzoxazol-
• 6-yl)-N-methyl-benzamide,
• 77
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-methyl-N-(2-
• methylimidazo[1,2-a]pyridin-6-yl)benzamide,
• 78
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-methyl-N-[2-
• (trifluoromethyl)-1,3-benzoxazol-5-yl]benzamide,
• 79
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-methyl-N-(2-methyl-
• [1,2,4]triazolo[1,5-a]pyridin-6-yl)benzamide,
• 80
• 3-(4-chloro-3,5-dimethyl-pyrazol-1-yl)-N-(5-chloro-2-methyl-
• 1,3-benzoxazol-6-yl)-N-methyl-benzamide,
• 81
• N-(1,3-benzodioxol-5-yl)-3-(4-cyano-3,5-dimethyl-pyrazol-1-
• yl)-N-methyl-benzamide,
• 82
• N-(1,3-benzodioxol-5-yl)-3-(4-chloro-3,5-dimethyl-pyrazol-1-
• yl)-N,4-dimethyl-benzamide,
• 83
• 2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-4-chloro-
• 5-methyl-pyrazole-3-carboxylic acid,
• 84
• 2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-4-chloro-
• 5-methyl-pyrazole-3-carboxamide,
• 85
• 2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-4-chloro-
• N,5-dimethyl-pyrazole-3-carboxamide,
• 86
• ethyl 1-[3-[1,3-benzodioxol-5-yl(methyl) carbamoyl]phenyl]-4-
• chloro-5-isopropyl-pyrazole-3-carboxylate,
• 87
• ethyl 2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl] phenyl]-4-
• chloro-5-isopropyl-pyrazole-3-carboxylate,
• 88
• 2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-4-
• chloro-N,N,5-trimethyl-pyrazole-3-carboxamide,
• 89
• tert-butyl 2-[3-[1,3-benzodioxol-5-yl(methyl) carbamoyl]phenyl]-
• 4-chloro-5-methyl-pyrazole-3-carboxylate,
• 90
• N-(1,3-benzodioxol-5-yl)-3-[4-chloro-5-methyl-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 91
• N-(1,3-benzodioxol-5-yl)-N-methyl-3-[5-methyl-3-
• (trifluoromethyl)pyrazol-1-yl]benzamide,
• 92
• N-(1,3-benzodioxol-5-yl)-3-(4-chloro-3,5-diethyl-pyrazol-1-yl)-
• N-methyl-benzamide,
• 93
• N-(1,3-benzodioxol-5-yl)-3-(3,5-diethylpyrazol-1-yl)-N-
• methyl-benzamide,
• 94
• N-(1,3-benzodioxol-5-yl)-3-(4-chloro-5-cyclopropyl-3-methyl-
• pyrazol-1-yl)-N-methyl-benzamide,
• 95
• 3-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-N-(2,2-
• difluoro-1,3-benzodioxol-5-yl)-N-methyl-benzamide,
• 96
• 3-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-N-(2,3-
• dihydro-1,4-benzodioxin-6-yl)-N-methyl-benzamide,
• 97
• N-(1,3-benzodioxol-5-yl)-3-(5-cyclopropyl-3-methyl-pyrazol-
• 1-yl)-N-methyl-benzamide,
• 98
• N-(1,3-benzodioxol-5-yl)-3-[4-bromo-5-methyl-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 99
• N-(1,3-benzodioxol-5-yl)-3-[3,5-dimethyl-4-(trifluoromethyl)-
• pyrazol-1-yl]-N-methyl-benzamide,
• 100
• N-(1,3-benzodioxol-5-yl)-3-[5-isobutyl-3-(trifluoromethyl)-
• pyrazol-1-yl]-N-methyl-benzamide,
• 101
• N-(1,3-benzodioxol-5-yl)-3-[4-chloro-5-isobutyl-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 102
• N-(1,3-benzodioxol-5-yl)-3-[4-chloro-3-methyl-5-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 103
• ethyl 4-chloro-2-[3-[2,3-dihydro-1,4-benzodioxin-6-yl(methyl)carbamoyl]phenyl]-5-
• methyl-pyrazole-3-carboxylate,
• 104
• N-(1,3-benzodioxol-5-yl)-3-[4-cyclopropyl-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-
• N-methyl-benzamide,
• 105
• N-(1,3-benzodioxol-5-yl)-3-[4-chloro-5-(hydroxymethyl)-3-
• methyl-pyrazol-1-yl]-N-methyl-benzamide,
• 106
• N-(6-chloro-1,3-benzodioxol-5-yl)-3-[4-chloro-5-methyl-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 107
• N-(1,3-benzodioxol-5-yl)-3-[4-chloro-5-(methoxymethyl)-3-
• methyl-pyrazol-1-yl]-N-methyl-benzamide,
• 108
• 3-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-N-methyl-
• N-(2-methyl-1,3-benzoxazol-6-yl)benzamide,
• 109
• N-(1,3-benzodioxol-5-yl)-3-[4-chloro-5-[(R)-hydroxy
• (phenyl)methyl]-3-methyl-pyrazol-1-yl]-N-methyl-benzamide,
• 110
• N-(6-chloro-1,3-benzodioxol-5-yl)-3-[4-chloro-5-isobutyl-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 111
• N-(1,3-benzodioxol-5-yl)-3-[4-chloro-5-cyclopropyl-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 112
• N-(1,3-benzodioxol-5-yl)-3-(4-chloro-5-formyl-3-methyl-
• pyrazol-1-yl)-N-methyl-benzamide,
• 113
• N-(1,3-benzodioxol-5-yl)-3-[4-chloro-5-ethoxy-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 114
• N-(1,3-benzodioxol-5-yl)-3-[4-chloro-5-[(1R)-1-hydroxyethyl]-
• 3-methyl-pyrazol-1-yl]-N-methyl-benzamide,
• 115
• N-(1,3-benzodioxol-5-yl)-3-[4-chloro-5-(1-hydroxy-1-methyl-
• ethyl)-3-methyl-pyrazol-1-yl]-N-methyl-benzamide,
• 116
• 3-(5-acetyl-4-chloro-3-methyl-pyrazol-1-yl)-N-(1,3-benzodioxol-
• 5-yl)-N-methyl-benzamide,
• 117
• N-(1,3-benzodioxol-5-yl)-3-[4-chloro-5-[(R)-methoxy
• (phenyl)methyl]-3-methyl-pyrazol-1-yl]-N-methyl-benzamide,
• 118
• N-(1,3-benzodioxol-5-yl)-3-[4-chloro-3-methyl-5-
• (phenoxymethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 119
• N-(1,3-benzodioxol-5-yl)-3-(5-benzoyl-4-chloro-3-methyl-
• pyrazol-1-yl)-N-methyl-benzamide,
• 122
• 3-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-N-methyl-
• N-(2-methylindazol-6-yl)benzamide,
• 123
• N-(5-chloro-2-methyl-1,3-benzoxazol-6-yl)-3-[4-chloro-5-methyl-
• 3-(trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 124
• N-(1,3-benzodioxol-5-yl)-3-[4-chloro-5-phenyl-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 125
• N-(1,3-benzodioxol-5-yl)-N-methyl-3-[5-phenyl-3-
• (trifluoromethyl)pyrazol-1-yl]benzamide,
• 126
• N-(1,3-benzodioxol-5-yl)-3-[4-fluoro-5-methyl-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 129
• N-(1,3-benzodioxol-5-yl)-3-[4-chloro-3-methyl-5-(5-methyl-
• 1,3,4-oxadiazol-2-yl)pyrazol-1-yl]-N-methyl-benzamide,
• 130
• ethyl 2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-5-
• (trifluoromethyl)pyrazole-3-carboxylate,
• 131
• N-(1,3-benzodioxol-5-yl)-3-[5-isopropoxy-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 132
• N-(1,3-benzodioxol-5-yl)-3-[5-benzyloxy-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 133
• N-(1,3-benzodioxol-5-yl)-N-methyl-3-[5-phenethyloxy-3-
• (trifluoromethyl)pyrazol-1-yl]benzamide,
• 134
• N-(1,3-benzodioxol-5-yl)-3-[5-benzyloxy-4-chloro-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 135
• 3-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-yl]-N-
• ethyl-N-(2-methyl-1,3-benzoxazol-6-yl)benzamide,
• 137
• 3-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-yl]-N-
• methyl-N-(2-methyl-1,3-benzoxazol-6-yl)benzamide,
• 139
• 3-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-yl]-N-
• (5-chloro-2-methyl-1,3-benzoxazol-6-yl)-N-methyl-benzamide,
• 140
• ethyl 3-[[2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl] phenyl]-
• 4-chloro-5-methyl-pyrazol-3-yl]methoxy]benzoate,
• 141
• ethyl 4-[[2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl] phenyl]-
• 4-chloro-5-methyl-pyrazol-3-yl]methoxy]benzoate,
• 142
• N-(1,3-benzodioxol-5-yl)-3-[4-chloro-5-isopropoxy-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 143
• 3-[[2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-4-
• chloro-5-methyl-pyrazol-3-yl]methoxy]benzoic acid,
• 144
• 4-[[2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-4-
• chloro-5-methyl-pyrazol-3-yl]methoxy]benzoic acid,
• 145
• tert-butyl 2-[[3-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)-
• pyrazol-1-yl]benzoyl]-(2-methyl-1,3-benzoxazol-6-
• yl)amino]acetate,
• 146
• 2-[[3-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-
• yl]benzoyl]-(2-methyl-1,3-benzoxazol-6-yl)amino]acetic acid,
• 147
• N-(1,3-benzodioxol-5-yl)-3-[5-(2-furyl)-3-(trifluoromethyl)-
• pyrazol-1-yl]-N-methyl-benzamide,
• 149
• 3-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-N-methyl-
• N-(2-methyl-1,3-benzothiazol-6-yl)benzamide,
• 150
• ethyl 4-[[2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl] phenyl]-
• 4-chloro-5-(trifluoromethyl)pyrazol-3-yl]methoxy]benzoate,
• 151
• 4-[[2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-4-
• chloro-5-(trifluoromethyl)pyrazol-3-yl]methoxy]benzoic acid,
• 152
• methyl 4-[[2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-
• 5-(trifluoromethyl)pyrazol-3-yl]oxymethyl]benzoate,
• 154
• 3-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-N-(5-
• fluoro-2-methyl-1,3-benzoxazol-6-yl)-N-methyl-benzamide,
• 155
• methyl 4-[[2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl] phenyl]-
• 4-chloro-5-(trifluoromethyl)pyrazol-3-yl]oxymethyl]benzoate,
• 156
• methyl 4-[[4-chloro-2-[3-[(6-chloro-1,3-benzodioxol-5-yl)-
• methyl-carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxymethyl]benzoate,
• 157
• tert-butyl 4-[2-[3-[1,3-benzodioxol-5-yl(methyl) carbamoyl]-
• phenyl]-4-chloro-5-(trifluoromethyl)pyrazol-3-yl]oxypiperidine-
• 1-carboxylate,
• 158
• N-(1,3-benzodioxol-5-yl)-3-[5-ethoxy-3-(trifluoromethyl)
• pyrazol-1-yl]-N-methyl-benzamide,
• 159
• 4-[[2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-
• 4-chloro-5-(trifluoromethyl)pyrazol-3-yl]oxymethyl]
• benzoic acid,
• 161
• 3-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-N-(6-
• formyl-1,3-benzodioxol-5-yl)-N-methyl-benzamide,
• 163
• 3-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-N-(6-
• cyano-1,3-benzodioxol-5-yl)-N-methyl-benzamide,
• 164
• N-(1,3-benzodioxol-5-yl)-3-[5-(5-chloro-2-thienyl)-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 166
• N-(1,3-benzodioxol-5-yl)-N-methyl-3-[5-(2-thienyl)-3-
• (trifluoromethyl)pyrazol-1-yl]benzamide,
• 168
• 3-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-N-[6-
• (hydroxymethyl)-1,3-benzodioxol-5-yl]-N-methyl-benzamide,
• 169
• N-(1,3-benzodioxol-5-yl)-N-methyl-2-[3-methyl-5-
• (trifluoromethyl)pyrazol-1-yl]pyridine-4-carboxamide,
• 170
• N-(1,3-benzodioxol-5-yl)-2-[4-chloro-3-methyl-5-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-pyridine-4-carboxamide,
• 171
• N-(1,3-benzodioxol-5-yl)-2-[4-chloro-5-methyl-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-pyridine-4-carboxamide,
• 175
• tert-butyl 4-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-
• yl)-methyl-carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]benzoate,
• 176
• N-(1,3-benzodioxol-5-yl)-N-methyl-3-[3-(trifluoromethyl)-5-[2-
• (trifluoromethyl)phenyl]pyrazol-1-yl]benzamide,
• 177
• 4-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-carbamoyl]phenyl]-5-
• (trifluoromethyl)pyrazol-3-yl]methoxy]benzoic acid,
• 179
• 6-[[3-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-
• benzoyl]-methyl-amino]-1,3-benzodioxole-5-carboxylic acid,
• 180
• N-(1,3-benzodioxol-5-yl)-3-[4-formyl-5-phenoxy-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 183
• N-(1,3-benzodioxol-5-yl)-3-[4-chloro-5-(2-methoxyphenyl)-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 184
• N-(1,3-benzodioxol-5-yl)-3-[5-(2-methoxyphenyl)-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 185
• N-(1,3-benzodioxol-5-yl)-3-[4-cyano-5-phenoxy-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 186
• N-(1,3-benzodioxol-5-yl)-3-[4-formyl-5-methyl-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 187
• N-(1,3-benzodioxol-5-yl)-3-[4-cyano-5-methyl-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 188
• tert-butyl 4-[[2-[3-[methyl-(2-methyl-1,3-benzoxazol-6-
• yl)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxymethyl]benzoate,
• 189
• tert-butyl 4-[[2-[3-[(5-fluoro-2-methyl-1,3-benzoxazol-6-yl)-
• methyl-carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxymethyl]benzoate,
• 190
• tert-butyl 4-[[4-chloro-2-[3-[methyl-(2-methyl-1,3-benzoxazol-6-
• yl)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxymethyl]benzoate,
• 191
• tert-butyl 4-[[2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxymethyl]benzoate,
• 192
• N-(1,3-benzodioxol-5-yl)-N-methyl-3-[3-(2-pyridyl)-5-
• (trifluoromethyl)pyrazol-1-yl]benzamide,
• 193
• N-(1,3-benzodioxol-5-yl)-N-methyl-3-[5-(3-pyridyl)-3-
• (trifluoromethyl)pyrazol-1-yl]benzamide,
• 194
• N-(1,3-benzodioxol-5-yl)-N-methyl-3-[3-(3-pyridyl)-5-
• (trifluoromethyl)pyrazol-1-yl]benzamide,
• 195
• 4-[[2-[3-[methyl-(2-methyl-1,3-benzoxazol-6-yl)carbamoyl]-
• phenyl]-5-(trifluoromethyl)pyrazol-3-yl]oxymethyl]benzoic acid,
• 196
• 4-[[2-[3-[(5-fluoro-2-methyl-1,3-benzoxazol-6-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxymethyl]benzoic acid,
• 197
• 4-[[2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxymethyl]benzoic acid,
• 198
• 4-[[4-chloro-2-[3-[methyl-(2-methyl-1,3-benzoxazol-6-
• yl)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxymethyl]benzoic acid,
• 200
• tert-butyl 4-[2-[3-[1,3-benzodioxol-5-yl(methyl) carbamoyl]
• phenyl]-4-cyano-5-(trifluoromethyl)pyrazol-3-yl]oxybenzoate,
• 201
• tert-butyl 4-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-
• 5-yl)-methyl-carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxymethyl]benzoate,
• 202
• tert-butyl 4-[[4-chloro-2-[3-[(5-fluoro-2-methyl-1,3-benzoxazol-
• 6-yl)-methyl-carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxymethyl]benzoate,
• 204
• N-(1,3-benzodioxol-5-yl)-N-methyl-3-[5-methyl-3-
• (trifluoromethyl)pyrazol-1-yl]benzenesulfonamide,
• 207
• 3-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-N-(4-
• formyl-1,3-benzodioxol-5-yl)-N-methyl-benzamide,
• 208
• 5-[[3-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-
• benzoyl]-methyl-amino]-1,3-benzodioxole-4-carboxylic acid,
• 209
• 3-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-N-[4-
• (hydroxymethyl)-1,3-benzodioxol-5-yl]-N-methyl-benzamide,
• 210
• 4-[2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-4-
• cyano-5-(trifluoromethyl)pyrazol-3-yl]oxybenzoic acid,
• 211
• 4-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxymethyl]benzoic acid,
• 212
• 4-[[4-chloro-2-[3-[(5-fluoro-2-methyl-1,3-benzoxazol-6-yl)-
• methyl-carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxymethyl]benzoic acid,
• 213
• ethyl-cis-4-[2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]-
• phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxycyclohexanecarboxylate,
• 214
• ethyl 4-[2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl] phenyl]-
• 5-(trifluoromethyl)pyrazol-3-yl]oxycyclo hexanecarboxylate,
• 215
• 4-[2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-5-
• (trifluoromethyl)pyrazol-3-yl]oxycyclohexanecarboxylic acid,
• 216
• cis-4-[2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl] phenyl]-5-
• (trifluoromethyl)pyrazol-3-yl]oxycyclo hexanecarboxylic acid,
• 217
• 3-[4-chloro-5-(hydroxymethyl)-3-(trifluoromethyl) pyrazol-1-
• yl]-N-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-methyl-benzamide,
• 218
• 4-[[2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]benzoic acid,
• 219
• 3-[4-chloro-5-isobutyl-3-(trifluoromethyl)pyrazol-1-yl]-N-
• (2,2-difluoro-1,3-benzodioxol-5-yl)-N-methyl-benzamide,
• 220
• N-(2,2-difluoro-1,3-benzodioxol-5-yl)-3-[4-fluoro-5-methyl-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-benzamide,
• 221
• 3-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)pyrazol-1-yl]-N-
• (2,2-difluoro-1,3-benzodioxol-5-yl)-N-methyl-benzamide,
• 222
• 4-[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxycyclohexanecarboxylic acid,
• 223
• 4-[[4-cyano-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-
• (trifluoromethyl)pyrazol-3-yl]oxymethyl]benzoic acid,
• 224
• 4-[[4-cyano-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-
• (trifluoromethyl)pyrazol-3-yl]methoxy]benzoic acid,
• 225
• 2-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-
• 3-yl]methoxy]thiazole-5-carboxylic acid,
• 226
• 5-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-
• 3-yl]methoxy]pyrazine-2-carboxylic acid,
• 227
• 3-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-yl]methoxy]bicyclo[1.1.1]pentane-1-carboxylic acid,
• 228
• Trans-4-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-
• methyl-carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]cyclohexanecarboxylic acid,
• 229
• 3-[2-[3-[methyl-(2-methyl-1,3-benzoxazol-6-yl)carbamoyl]-
• phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxycyclobutanecarboxylic acid,
• 230
• N-(1,3-benzodioxol-5-yl)-4-[4-chloro-5-methyl-3-
• (trifluoromethyl)pyrazol-1-yl]-N-methyl-pyridine-2-carboxamide,
• 231
• 4-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-yl]methoxy]-2-
• fluoro-benzoic acid,
• 232
• 1-[2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-4-
• chloro-5-(trifluoromethyl)pyrazol-3-yl]piperidine-4-carboxylic
• acid,
• 233
• 4-[[4-chloro-2-[3-[methyl-(2-methyl-1,3-benzoxazol-6-
• yl)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]benzoic acid,
• 234
• 4-[[4-chloro-2-[3-[(5-fluoro-2-methyl-1,3-benzoxazol-6-yl)-
• methyl-carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]benzoic acid,
• 235
• 4-[1-[2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-
• 4-chloro-5-(trifluoromethyl)pyrazol-3-yl]-1-methyl-
• ethoxy]benzoic acid,
• 236
• 4-[[4-chloro-2-[3-[methyl-(2-methyl-[1,2,4]triazolo[1,5-
• a]pyridin-6-yl)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-
• 3-yl]methoxy]benzoic acid,
• 237
• 4-[[4-chloro-2-[3-[methyl-(3-methyl-1H-pyrazolo[3,4-
• b]pyridin-5-yl)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-
• 3-yl]methoxy]benzoic acid,
• 238
• 4-[[4-chloro-2-[3-[methyl-(2-methylpyrazolo[1,5-a]pyrimidin-6-
• yl)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]benzoic acid,
• 239
• 4-[[4-chloro-2-[3-[methyl-(2-methylpyrazolo[1,5-a]pyridin-5-
• yl)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]benzoic acid,
• 240
• 4-[[4-chloro-2-[3-[methyl(6-quinolyl)carbamoyl]phenyl]-5-
• (trifluoromethyl)pyrazol-3-yl]methoxy]benzoic acid,
• 241
• 4-[[4-chloro-2-[3-[methyl-(2-methyloxazolo[4,5-b]pyridin-6-
• yl)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]benzoic acid,
• 242
• 1-[2-[3-[1,3-benzodioxol-5-yl(methyl)carbamoyl]phenyl]-
• 4-chloro-5-(trifluoromethyl)pyrazol-3-yl]azetidine-3-
• carboxylic acid,
• 243
• 4-[[4-chloro-2-[5-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]-3-pyridyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]benzoic acid,
• 244
• 4-[[4-chloro-2-[3-[(1,1-dioxo-2,3-dihydrobenzothiophen-
• 6-yl)-methyl-carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]benzoic acid,
• 245
• 4-[[4-chloro-2-[3-[methyl-(3-methyl-1,2-benzoxazol-6-
• yl)carbamoyl]phenyl]-5-
• (trifluoromethyl)pyrazol-3-yl]methoxy]benzoic acid,
• 246
• 3-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]isoxazole-5-carboxylic acid,
• 247
• 4-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]pyrrolidine-2-carboxylic acid,
• 248
• 6-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]pyridine-3-carboxylic acid,
• 249
• 4-[[4-chloro-2-[3-[(3-hydroxyindan-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]benzoic acid,
• 250
• 4-[[4-chloro-2-[3-[(2,2-difluoro-[1,3]dioxolo[4,5-b]pyrazin-
• 5-yl)-methyl-carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]benzoic acid,
• 251
• 4-[[4-chloro-2-[3-[methyl-(2-methyloxazolo[4,5-b]pyridin-6-
• yl)carbamoyl]phenyl]-5-
• (trifluoromethyl)pyrazol-3-yl]methoxy]benzoic acid,
• 252
• N-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-methyl-3-[5-
• methyl-3-(p-tolylmethoxy)-6,7-
• dihydro-4H-pyrazolo[4,3-c]pyridin-2-yl]benzamide,
• 253
• N-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-methyl-3-[3-(p-
• tolylmethoxy)-4,5,6,7-tetrahydroindazol-2-yl]benzamide,
• 254
• methyl 3-[[2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxymethyl]bicyclo[1.1.1]pentane-1-carboxylate,
• 255
• 3-[[2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxymethyl]bicyclo[1.1.1]pentane-1-carboxylic acid,
• 256
• 4-[[4-chloro-2-[3-[methyl-(2-methylimidazo[1,2-a]pyridin-6-
• yl)carbamoyl]phenyl]-5-
• (trifluoromethyl)pyrazol-3-yl]methoxy]benzoic acid,
• 257
• 3-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]cyclobutanecarboxylic acid,
• 258
• 3-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxymethyl]bicyclo[1.1.1]pentane-1-carboxylic acid,
• 259
• tert-butyl 4-[[4-cyano-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-
• methyl-carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]benzoate,
• 260
• ethyl 4-[4-[2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-yl]oxy-1-
• piperidyl]-4-oxo-butanoate,
• 261
• 3-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-N-methyl-
• N-(2-methyloxazolo[4,5-b]pyridin-6-yl)benzamide,
• 262
• 4-[[2-[3-[2,3-dihydrobenzofuran-6-yl(methyl)carbamoyl]phenyl]-
• 5-(trifluoromethyl)pyrazol-3-yl]oxymethyl]benzoic acid,
• 263
• 4-[[2-[3-[methyl-(3-methyl-1,2-benzoxazol-6
• -yl)carbamoyl]phenyl]-5-
• (trifluoromethyl)pyrazol-3-yl]oxymethyl]benzoic acid,
• 264
• 4-[4-[2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-yl]oxy-
• 1-piperidyl]-4-oxo-butanoic acid,
• 265
• 1-[[2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxymethyl]cyclopropanecarboxylic acid,
• 266
• 4-[[2-[3-[(5-fluoro-2-methyl-1,3-benzoxazol-6-yl)-methyl-
• carbamoyl]phenyl]-5-
• (trifluoromethyl)pyrazol-3-yl]methoxy]benzoic acid,
• 267
• 4-[[4-chloro-2-[3-[[1,3]dioxolo[4,5-b]pyridin-6-
• yl(methyl)carbamoyl]phenyl]-5-
• (trifluoromethyl)pyrazol-3-yl]methoxy]benzoic acid,
• 268
• 4-[[4-cyano-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-
• methyl-carbamoyl]phenyl]-5-
• (difluoromethyl)pyrazol-3-yl]methoxy]benzoic acid,
• 269
• 3-[4-chloro-5-methyl-3-(trifluoromethyl)pyrazol-1-yl]-N-
• methyl-N-(4-methyl-1,3-benzodioxol-5-yl)benzamide,
• 270
• 4-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-
• methyl-carbamoyl]phenyl]-5-
• (difluoromethyl)pyrazol-3-yl]methoxy]benzoic acid,
• 271
• 4-[[4-chloro-5-(difluoromethyl)-2-[3-[methyl-(2-methyl-1,3-
• benzoxazol-6-yl)carbamoyl]phenyl]pyrazol-3-
• yl]methoxy]benzoic acid,
• 272
• 4-[[4-chloro-2-[3-[[2-(difluoromethoxy)pyrimidin-5-yl]-
• methyl-carbamoyl]phenyl]-5-
• (trifluoromethyl)pyrazol-3-yl]methoxy]benzoic acid,
• 273
• 4-[[4-chloro-5-(difluoromethyl)-2-[3-[methyl-(2-methyl-1,3-
• benzoxazol-6-yl)carbamoyl]phenyl]pyrazol-
• 3-yl]oxymethyl]benzoic acid,
• 274
• 4-[[2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-
• (difluoromethyl)pyrazol-3-yl]methoxy]benzoic acid,
• 275
• 4-[[4-chloro-2-[3-[(2,2-difluoro-3H-furo[3,2-b]pyridin-6-
• yl)-methyl-carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]benzoic acid,
• 276
• 4-[[4-cyano-5-(difluoromethyl)-2-[3-[methyl-(2-
• methyloxazolo[4,5-b]pyridin-6-
• yl)carbamoyl]phenyl]pyrazol-3-yl]methoxy]benzoic acid,
• 277
• 6-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]pyridazine-3-carboxylic acid,
• 278
• 4-[[4-chloro-2-[3-[methyl-(2-methylpyrazolo[1,5-a]pyrimidin-
• 6-yl)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]oxymethyl]benzoic acid,
• 279
• 5-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]pyridine-2-carboxylic acid,
• 280
• 6-[[4-chloro-2-[3-[[2-(difluoromethoxy)pyrimidin-5-yl]-
• methyl-carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]pyridine-3-carboxylic acid,
• 281
• 5-[[2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]pyridine-2-carboxylic acid,
• 282
• 2-[[4-chloro-2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-
• cmethyl-arbamoyl]phenyl]-5-(trifluoromethyl)pyrazol-3-
• yl]methoxy]pyridine-4-carboxylic acid,
• 283
• 4-[[4-cyano-2-[3-[[2-(difluoromethoxy)pyrimidin-5-yl]-
• methyl-carbamoyl]phenyl]-5-methyl-pyrazol-3-
• yl]methoxy]benzoic acid,
• 284
• 4-[[4-cyano-5-methyl-2-[3-[methyl-(2-methyloxazolo[4,5-
• b]pyridin-6-yl)carbamoyl]phenyl]pyrazol-3-
• yl]methoxy]benzoic acid,
• 285
• 4-[[5-methyl-2-[3-[methyl-(2-methylpyrazolo[1,5-a]pyrimidin-
• 6-yl)carbamoyl]phenyl]pyrazol-3-yl]oxymethyl]benzoic acid,
• 286
• 4-[[2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-4,5,6,7-
• tetrahydroindazol-3-yl]oxymethyl]benzoic acid,
• and,
• 287
• 4-[[2-[3-[(2,2-difluoro-1,3-benzodioxol-5-yl)-methyl-
• carbamoyl]phenyl]-5-methyl-6,7-dihydro-4H-pyrazolo[4,3-
• c]pyridin-3-yl]oxymethyl]benzoic acid.