Hydroxytriazine compounds and pharmaceutical use thereof
AssigneeJapan Tobacco Inc.
InventorsIkuo Mitani, Yutaro Hirono, Masaki Yamashita
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Abstract
The present invention provides a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and/or cancer including colorectal cancer. The present invention relates to a compound of formula [I-a], [I-b] or [I-c] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the specification.
Claims9
A compound of the formula [I-c], or a pharmaceutically acceptable salt thereof:
- wherein
- R is
- (1) the formula:
- wherein
- R1a is C1-4 alkyl,
- R1b is C1-4 alkyl or trifluoromethyl, and
- R1c is
- (a) C1-4 alkyl,
- (b) C1-4 fluoroalkyl,
- (c) C1-4 alkoxy, or
- (d) C1-4 alkoxy C1-4 alkyl, or
- (2) the formula:
- wherein
- n is 1,2, 3, 4 or 5, and
- R1d is
- (a) fluoro,
- (b) C1-4 alkyl,
- (c) C1-4 fluoroalkyl,
- (d) C1-4 alkoxy, or
- (e) C1-4 alkoxy C1-4 alkyl,
- R2 is hydrogen, and
- R6 is 1-methylbutyl or n-hexyl.
A compound selected from the following formulas:
- or a pharmaceutically acceptable salt thereof.
A compound of the following formula or a pharmaceutically acceptable salt thereof:
A compound of the following formula:
Dependencies are inferred from the claim text.