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US 12,492,180 B2Granted
Process and intermediates for the preparation of Voxelotor
AssigneeCuria Spain, S.A.U.
InventorsJuan José Ferreiro Gil, Jesús Miguel Iglesias Retuerto, Antonio Lorente Bonde-Larsen
Life of this patent
Estimating the term…
Abstract
The invention relates to a process for the preparation of Voxelotor, or a salt or solvate thereof, which comprises the use of a compound of formula (I) or (I′), or a salt or solvate thereof.
Claims9
A process for preparing Voxelotor
- or a salt or solvate thereof, comprising:
- (a) reacting a compound of formula (I)
- or a salt or solvate thereof, wherein
- R3 represents hydrogen or a hydroxyl protecting group,
- R4 and R4′ are independently selected from C1-6 alkyl and C1-6 alkoxyl;
- with a compound of formula (II)
- or a salt or solvate thereof, wherein X is selected from OH, Cl, Br, I, OTf, OTs and OMs;
- to obtain a compound of formula (IV)
- or a salt or solvate thereof, and
- (b) converting the compound of formula (IV), or a salt or solvate thereof, into Voxelotor or a salt or solvate thereof.
7 more elements
A process for preparing Voxelotor
- or a salt or solvate thereof comprising:
- (a) reacting a compound of formula (I)
- or a salt or solvate thereof, wherein
- R3 represents hydrogen or a hydroxyl protecting group,
- R4 and R4′ are independently selected from C1-6 alkyl and C1-6 alkoxyl;
- with a compound of formula (III)
- or a salt or solvate thereof, wherein
- X is selected from OH, Cl, Br, I, OTf, OTs and OMs, and
- Y is selected from Cl, Br, I, OTf and OMs;
- to obtain a compound of formula (V)
- or a salt or solvate thereof,
- (b) reacting the compound of formula (V), or a salt or solvate thereof,
- with a compound of formula (VIII)
- or a salt or solvate thereof, wherein each R2 is independently selected from the group consisting of OH, C1-6 alkyl, C3-7 cycloalkyl, C1-6 alkoxyl, or together they form a C2-3 alkylenedioxy group optionally substituted by C1-6 alkyl, or a benzyldioxy group optionally substituted by C1-6 alkyl, or the —B(R2)2 group is —BF3K;
- to provide a compound of formula (IV)
- or a salt or solvate thereof, and
- (c) converting the compound of formula (IV), or a salt or solvate thereof, into Voxelotor or a salt or solvate thereof.
14 more elements
Dependencies are inferred from the claim text.