Heterocyclic inhibitors of MCT4
AssigneeVettore, LLC
InventorsKenneth Mark Parnell, John McCall, Donna Romero
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Abstract
Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the structure of Formula I: Methods of inhibition MCT4 activity in a human or animal subject are also provided.
Claims9
A method for treating idiopathic pulmonary fibrosis in a subject in need thereof, comprising administering to the subject a compound of structural Formula VIII:
- or a salt thereof, wherein:
- L is chosen from a bond and methylene;
- Y is chosen from
- R2c is chosen from H, C1-C4alkoxy and C1-C4cycloalkoxy;
- R2d is chosen from null and C1-C4alkoxy;
- R2e is C1-C4alkyl;
- n is 1 or 2;
- R4 and R5 are independently chosen from C1-C3alkyl;
- and
- R6 is chosen from H and C1-C4alkyl.
A method for treating idiopathic pulmonary fibrosis in a subject in need thereof, comprising administering to the subject a compound of structural Formula XI:
- or a salt thereof, wherein:
- W is chosen from
- m is 1, 2, or 3;
- L is chosen from a bond and methylene;
- Z is chosen from
- n is 1 or 2;
- R4 and R5 are independently chosen from C1-C3alkyl;
- R6 is chosen from H and C1-C4alkyl;
- and
- R9 is chosen from halo, amino, and C1-C4alkoxy.
A method for treating idiopathic pulmonary fibrosis in a subject in need thereof, comprising administering to the subject a compound of structural formula:
- or a salt thereof.
Dependencies are inferred from the claim text.