Sulfonylurea derivative and medical uses thereof
AssigneesShanghai Senhui Medicine Co., Ltd., Shanghai Shengdi Pharmaceutical Co., Ltd., Jiangsu Hengrui Pharmaceuticals Co., Ltd.
InventorsJian Huang, Lingjian Zhu, Xiuzhao Yu, Piaoyang Sun
Life of this patent
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Abstract
The present invention relates to a sulfonylurea derivative and medical uses thereof, specifically relating to the sulfonylurea derivative shown in general formula (I), a preparation method thereof, a pharmaceutical composition containing same, and a use of same for treating diseases and disorders affected by neuronal damage, for example: cerebral stroke, brain damage, neuropathic pain, migraines, inflammatory pain, chronic pain, or depression. The definition of each group in the general formula (I) is the same as that in the description.
Claims18
A compound of general formula (I), or a pharmaceutically acceptable salt thereof,
- wherein,
- each R1 is independently selected from the group consisting of deuterium, alkyl optionally substituted with halogen, halogen, hydroxy, mercapto, —NRiRj, —C(O)Rk, —C(O)ORk, nitro, cyano, alkoxy optionally substituted with halogen, and alkylthio;
- R2 is selected from the group consisting of alkyl, alkoxy, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl and heterocyclyl, wherein the alkyl, alkoxy, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl and heterocyclyl are optionally further substituted with one or more groups selected from the group consisting of deuterium, alkyl, haloalkyl, halogen, hydroxy, oxo, mercapto, —NRiRj, —C(O)Rk, —C(O)ORk, —SRi, —S(O)Ri, —SO2Ri, nitro, cyano, aryl optionally substituted with hydroxy or alkoxy, heteroaryl optionally substituted with oxo or alkyl, heterocyclyl optionally substituted with oxo or alkyl, cycloalkyl optionally substituted with oxo or alkyl, optionally substituted alkenyl, optionally substituted alkynyl, alkoxy, and alkylthio;
- each R3 is independently selected from the group consisting of deuterium, alkyl optionally substituted with halogen, halogen, hydroxy, mercapto, —NRiRj, —C(O)Rk, —C(O)ORk, nitro, cyano, alkoxy, and alkylthio;
- Ri and Rj are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, cycloalkyl, alkoxy, and —C(═NH)—NH2;
- Rk is selected from the group consisting of alkyl, alkoxy, aryl, alkenyl and alkynyl, wherein the alkyl, alkoxy, aryl, alkenyl and alkynyl are optionally further substituted with one or more groups selected from the group consisting of aryl, heteroaryl, heterocyclyl, cycloalkyl, alkyl and alkoxy;
- m is an integer selected from the group consisting of 0 to 5;
- n is an integer selected from the group consisting of 0 to 10;
- and
- R2 is not
A compound of general formula (I-1), or a pharmaceutically acceptable salt thereof,
- wherein,
- R2 is selected from the group consisting of alkyl, alkoxy, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl and heterocyclyl, wherein the alkyl, alkoxy, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl and heterocyclyl are optionally further substituted with one or more groups selected from the group consisting of deuterium, alkyl, haloalkyl, halogen, hydroxy, oxo, mercapto, —NRiRj, —C(O)Rk, —C(O)ORk, —SRi, —S(O)Ri, —SO2Ri, nitro, cyano, aryl optionally substituted with hydroxy and/or alkoxy, heteroaryl optionally substituted with oxo and/or alkyl, heterocyclyl optionally substituted with oxo and/or alkyl, cycloalkyl optionally substituted with oxo and/or alkyl, optionally substituted alkenyl, optionally substituted alkynyl, alkoxy, and alkylthio;
- Ri and Rj are each independently selected from the group consisting of hydrogen, hydroxy, alkyl, cycloalkyl, alkoxy, and —C(═NH)—NH2;
- Rk is selected from the group consisting of alkyl, alkoxy, aryl, alkenyl and alkynyl, wherein the alkyl, alkoxy, aryl, alkenyl and alkynyl are optionally further substituted with one or more groups selected from the group consisting of aryl, heteroaryl, heterocyclyl, cycloalkyl, alkyl and alkoxy;
- and R2 is not
A compound as shown below, or a pharmaceutically acceptable salt thereof,
A method for treating a disease or condition affected by neuronal damage in a subject in need thereof, the method comprising:
- administering to the subject a compound as shown below or a pharmaceutically acceptable salt thereof,
A method for treating a disease or condition affected by neuronal damage in a subject in need thereof, the method comprising:
- administering to the subject a compound as shown below or a pharmaceutically acceptable salt thereof,
Dependencies are inferred from the claim text.