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US 12,492,164 B2Granted
Fluorine substituted cyclohexene analogues of gamma-aminobutyric acid (GABA)
AssigneeNorthwestern University
InventorsRichard B. Silverman, Wei Zhu
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Abstract
Disclosed are amino, fluoro-substituted cyclohexene carboxylic acid compounds. The disclosed compounds and compositions thereof may be utilized in methods for modulating ornithine aminotransferase (OAT) activity, including methods for treating diseases or disorders associated with OAT activity or expression such as cell proliferative diseases and disorders.
Claims24
A compound of the following formula or a dissociated form, a non-protonated form, a zwitterion form, or a salt thereof:
- wherein a double bond is present between the α and ζ carbons or between the α and β carbons, and wherein each of R1 and R2 is independently selected from H or a leaving group, providing at least one of R1 and R2 is not H.
Dependencies are inferred from the claim text.