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US 12,492,163 B2Granted
9H-fluorene derivatives or their pharmaceutically acceptable salts
AssigneeUniwersytet Jagiellonski
InventorsDawid Panek, Barbara Malawska, Anna Pasieka, Jakub Jonczyk, Anna Wieckowska, Justyna Godyn, Natalia Szalaj, Marek Bajda, Kinga Salat
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Abstract
A group of novel 9H-fluorene derivatives suitable for the preparation of active substances for the treatment of Alzheimer's disease, in particular as multifunctional inhibitors of the BuChE and BACE1 enzymes and beta-amyloid aggregation.
Claims8
A compound of formula I:
- where:
- n is an integer with value 0 or 1,
- m is an integer with value 0 or 1,
- R1 is H or CH3,
- R2 is H or CH3,
- R3 is H, CH3, CF3, tert-butyl, cyclopropyl, cyclohexyl or:
- group, where R4 is:
- H, 2-, 3- or 4-OCH3, 2-, 3- or 4-CF3, 2-, 3- or 4-isopropyl, or tert-butyl,
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.