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US 12,492,160 B2Granted
Prodrugs of itaconate and methyl itaconate
AssigneesThe Johns Hopkins University, Institute of Organic Chemistry and Biochemistry of the AS CR, V.V.I.
InventorsBarbara Slusher, Mohameed Islam, Rana Rais, Luis Garza, Benjamin Bell, Pavel Majer, Lukas Tenora, Ivan Snajdr, Marcela Krecmerova
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Abstract
Prodrugs of itaconic acid and 1- and 4-methyl itaconic acid and their use for treating a disease, disorder, or condition associated with inflammation are disclosed.
Claims11
A compound of formula (I):
- and pharmaceutically acceptable salts thereof;
- wherein:
- R1 is
- wherein n is an integer selected from 1, 2, 3, and 4;
- R4 is —OR5, wherein R5 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl;
- and
- R2 is —OR3, wherein R3 is C1-C6 straight-chain or branched unsubstituted or substituted alkyl.
4 more elements
A compound having the structure:
A compound having the structure:
A compound having the structure:
Dependencies are inferred from the claim text.