# US 12,491,365 B2 · Selective high frequency spinal cord modulation for inhibiting pain, including cephalic and/or total body pain with reduced side effects, and associated systems and methods

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- Number: US 12,491,365 B2
- Document ID: US12491365B2
- Status: Granted
- Kind: B2
- Application number: 18/531,570
- Filed: 2023-12-06
- Published: 2024-10-31
- Granted: 2025-12-09
- Earliest claimed: 2011-09-08
- Assignees: Nevro Corporation
- Applicants: Nevro Corp.
- Inventors: James R. Thacker; Konstantinos Alataris; Bradford Evan Gliner
- Web page: https://patentgrep.com/patent/US12491365B2

## CPC

- A61N 1/36071: {Pain}
- A61N 1/0551: {Spinal or peripheral nerve electrodes}
- A61N 1/0558: {Anchoring or fixation means therefor}
- A61N 1/06: for high-frequency therapy
- A61N 1/36075: {Headache or migraine}
- A61N 1/36157: {Current (A61N1/3616 takes precedence)}
- A61N 1/36171: {Frequency}
- A61N 1/36175: {Pulse width or duty cycle}
- A61N 1/36185: {Selection of the electrode configuration}
- A61N 1/3616: {Voltage density or current density}
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)

## Abstract

Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal cord region from an epidural, cervical location to address at least one of high back pain, mid-back pain, low back pain, and leg pain without creating paresthesia in the patient.

## Claims

### Claim 1

A method for treating pelvic pain in a patient, the method comprising:
programming a signal generator to generate and deliver an electrical signal to a target sacral nerve of the patient via at least one implantable signal delivery device positionable proximate the target sacral nerve,
wherein the electrical signal has a frequency in a frequency range of from 1.5 kHz to 100 kHz, a pulse width in a pulse width range of from 10 microseconds to 333 microseconds, and an amplitude in an amplitude range of from 0.1 mA to 20 mA, and
wherein the electrical signal at least partially alleviates the pelvic pain.

### Claim 2 (depends on 1)

The method of claim 1 wherein the target sacral nerve includes the S2, S3, or S4 sacral nerve.

### Claim 3 (depends on 1)

The method of claim 1 wherein the implantable signal delivery device is positionable proximate a horsetail region of the sacrum to stimulate a portion of the target sacral nerve proximate the sacrum.

### Claim 4 (depends on 1)

The method of claim 1 wherein the pelvic pain is associated with interstitial cystitis.

### Claim 5 (depends on 1)

The method of claim 1 wherein the frequency range is from 3 kHz to 20 kHz.

### Claim 6 (depends on 1)

The method of claim 1 wherein the pulse width range is from 25 microseconds to 166 microseconds.

### Claim 7 (depends on 1)

The method of claim 1 wherein the frequency range is from 5 kHz to 15 kHz, the pulse width range is from 30 microseconds to 35 microseconds, and the amplitude range is from 0.5 mA to 10 mA.

### Claim 8 (depends on 1)

The method of claim 1 wherein the electrical signal does not generate paresthesia in the patient.

### Claim 9

A method for treating pelvic pain in a patient, the method comprising:
applying an electrical signal to a target sacral nerve of the patient via an implanted signal delivery device positioned proximate the target sacral nerve,
wherein the electrical signal has a frequency in a frequency range of from 1.5 kHz to 100 kHz, a pulse width in a pulse width range of from 10 microseconds to 333 microseconds, and an amplitude in an amplitude range of from 0.1 mA to 20 mA, and
wherein the electrical signal at least partially alleviates the pelvic pain.

### Claim 10 (depends on 9)

The method of claim 9, further comprising implanting the signal delivery device via a retrograde approach before applying the electrical signal.

### Claim 11 (depends on 9)

The method of claim 9 wherein the electrical signal has a frequency of 10 kHz.

### Claim 12 (depends on 9)

The method of claim 9 wherein the electrical signal is a paresthesia-free electrical signal.

### Claim 13 (depends on 9)

The method of claim 9 wherein the electrical signal is applied to a horsetail region of the sacrum that includes the target sacral nerve.

### Claim 14 (depends on 9)

The method of claim 9 wherein the target sacral nerve includes the S2, S3, or S4 sacral nerve.