Back to results
US 12,491,298 B2Granted
pH and buffer management system for hemodialysis systems
AssigneeMozarc Medical US LLC
InventorsBryant J. Pudil, Martin T. Gerber, David B. Lura, Thomas E. Meyer
Life of this patent
Estimating the term…
Abstract
Systems and methods for managing the pH of a dialysate fluid during hemodialysis therapy. The systems and methods adjust dialysate pH and buffer concentration to generate a predetermined total bicarbonate buffer concentration in a dialysate entering a dialyzer.
Claims15
A system comprising:
- a dialysate flow loop for circulating a dialysate through a dialyzer;
- a pH-buffer management system configured to modify a pH of the dialysate by converting bicarbonate within the dialysate to at least carbon dioxide dissolved within the dialysate,
- wherein the pH-buffer management system is upstream from a sorbent cartridge;
- a dialysate regeneration unit comprising the sorbent cartridge comprising at least one sorbent material;
- wherein the dialysate regeneration unit comprises a urea sensor;
- wherein the urea sensor measures a urea concentration in the dialysate before and after a urease layer of the sorbent cartridge;
- and
- a controller in communication with the urea sensor.
5 more elements
A method comprising:
- measuring a first urea concentration of a dialysate in a dialysate flow loop,
- wherein the first urea concentration is measured in a dialysate regeneration unit comprising a sorbent cartridge by a urea sensor;
- wherein the first urea concentration is measured before a urease layer of the sorbent cartridge;
- measuring a second urea concentration of the dialysate,
- wherein the second urea concentration is measured in the dialysate regeneration unit after the urease layer;
- determining a urea concentration of the dialysate using a difference between the first urea concentration and the second urea concentration;
- and
- modifying, by a pH-buffer management system in the dialysate flow loop, a pH of at least a portion of the dialysate by converting bicarbonate within the dialysate to at least carbon dioxide dissolved within the dialysate.
5 more elements
Dependencies are inferred from the claim text.