Pharmaceutical compositions for treating osteoarthritis
AssigneeInsignia Pharmaceuticals, LLC
InventorsDavid Bar-Or, Gregory Thomas, Melissa Hausburg, Jason Williams, Raphael Bar-Or
Life of this patent
Estimating the term…
Abstract
The present disclosure provides methods and compositions comprising hyaluronic acid (HA) hydrogel in combination with a saturated fatty acid for treating osteoarthritis. In some embodiments, aspects of the disclosure relate to pharmaceutical compositions comprising HA hydrogel in combination with a steroid. In some embodiments, the pharmaceutical compositions may be administrable via local, topical, and injection. In some embodiments, the pharmaceutical composition may be administrable by intra-articular injection.
Claims24
A pharmaceutical composition for use in a method of treating osteoarthritis, consisting of:
- a hyaluronic acid (HA) hydrogel comprising HA that has a molecular weight of at least 500 kilodaltons;
- water;
- and
- a saturated fatty acid at a concentration of at least 10 micromolar and up to 5 millimolar, wherein the composition is synergistically effective to reduce progression of osteoarthritis and to re-differentiate osteoarthritic chondrocytes.
Dependencies are inferred from the claim text.