Imaging histone deacetylases with a radiotracer using positron emission tomography
AssigneeThe General Hospital Corporation
InventorsJacob M. Hooker, Changning Wang, Frederick Albert Schroeder
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Abstract
Disclosed herein are histone deacetylase imaging agents for positron emission tomography and related imaging methods using the histone deacetylase imaging agents. The histone deacetylase imaging agents may be a compound of formula (I): wherein R1 is a moiety including a positron emitter; R2 represents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and n is an integer selected from 0 or 1. In one version of the compound of formula (I), R1 is a moiety including an adamantyl group.
Claims20
A compound of formula (II):
- wherein X represents a moiety other than hydrogen, and
- wherein the compound has a brain to plasma ratio greater than 1.
A compound of formula (I):
- wherein R1 is a moiety including a bridged carbocycle,
- wherein R2 represents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heterocyclic, wherein n is an integer selected from 0 or 1,
- wherein R1 is selected from the group consisting of
- and
- wherein the compound has a brain to plasma ratio greater than 1.
Dependencies are inferred from the claim text.