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US 12,491,268 B2Granted
Targeted protein contrast agents, methods of making, and uses thereof
AssigneeGeorgia State University Research Foundation, Inc.
InventorsJenny Jie Yang, Fan Pu, Shenghui Xue, Jingjuan Qiao, Shanshan Tan, Mani Salarian
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Abstract
Provided herein are protein contrast agents and targeted protein contrast agents, formulations thereof, and methods of use, including but not limited to, as a magnetic resonance imaging contrast agent.
Claims18
A protein contrast agent comprising:
- a parvalbumin polypeptide, wherein the parvalbumin polypeptide has the amino acid sequence comprising SEQ ID NO:
- 10;
- and
- a HER2 or HER1/EGFR targeting moiety directly fused or indirectly linked via a peptide linker to a terminus of the parvalbumin polypeptide.
1 more element
Dependencies are inferred from the claim text.