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US 12,491,258 B2Granted
Method for preparing long-acting drug conjugate through preparation of intermediate
AssigneeHanmi Pharm. Co., Ltd.
InventorsCheongbyeol Shin, Dooseo Jang, Ji Hye Moon, Dong Hyun Kim, Ji Eun Lee
Life of this patent
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Abstract
Provided is a novel method for preparing a long-acting drug conjugate and a long-acting drug conjugate prepared using the method.
Claims20
A compound having a structure of Formula 2 below or a stereoisomer, a solvate, or a pharmaceutically acceptable salt thereof:
- wherein in Formula 2 above, n is from 200 to 250, and wherein the immunoglobulin Fc region is derived from IgG, IgA, IgD, IgE, or IgM.
A composition for preparing a long-acting drug conjugate, comprising a compound having a structure of Formula 2 below, or a stereoisomer, a solvate, or a pharmaceutically acceptable salt thereof,
- wherein the drug is a physiologically active polypeptide:
- wherein in Formula 2 above, n is from 200 to 250, and
- wherein the immunoglobulin Fc region is derived from IgG, IgA, IgD, IgE, or IgM.
A method for preparing a long-acting conjugate of a physiologically active polypeptide, the method comprising:
- preparing a conjugate by linking a compound having a structure of Formula 2 below or a stereoisomer, a solvate, or a pharmaceutically acceptable salt thereof, to a physiologically active polypeptide:
- wherein in Formula 2 above, n is from 200 to 250, and
- wherein the immunoglobulin Fc region is derived from IgG, IgA, IgD, IgE, or IgM.
Dependencies are inferred from the claim text.