Vaccine
AssigneesUniversity of Surrey, The Secretary of State for Environment, Food and Rural Affairs Acting Through the Animal and Plant Health Agency
InventorsJohnjoe Mcfadden, Bernardo Villarreal-Ramos, Hans Martin Vordermeier, Graham Stewart
Life of this patent
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Abstract
The invention relates to modified Mycobacterium cells, and their uses as vaccines, and, particularly, modified Bacillus Calmette-Guérin vaccines. The invention extends to the use of the modified vaccines for vaccination applications in a wide range of animals, including cattle and humans. The invention extends to novel antigens, kits and compositions comprising these novel antigens and to their use in diagnosis. The invention also extends to apparatus comprising the modified vaccine and the antigens, and compositions comprising the antigens.
Claims10
An apparatus for tuberculosis vaccination and diagnosis, the apparatus comprising:
- (i) a vaccine comprising a mutant Mycobacterium cell, which has been modified compared to a corresponding wild-type cell, such that a plurality of genes, or products thereof, have been functionally deleted and/or inhibited, wherein the genes encode the native antigens esx-1 secretion-associated protein espA (espA), esat-6 like protein esxS (esxS), esx-1 secretion-associated protein espC (espC), major secreted immunogenic protein Mpb70 (MPB70), and cell surface lipoprotein Mpb83 (MPB83), or a homologue, paralogue, orthologue, functional fragment or variant thereof;
- and
- (ii) a composition configured to detect a Mycobacterium infection in a subject vaccinated with the vaccine of (i), the composition comprising the antigens of (i).
A mutant Mycobacterium cell, which has been modified compared to a corresponding wild-type cell, such that a plurality of genes, or products thereof, have been functionally deleted and/or inhibited, wherein the genes encode the antigens esx-1 secretion-associated protein espA (espA), esat-6 like protein esxS (esxS);
- esx-1 secretion-associated protein espC (espC);
- major secreted immunogenic protein Mpb70 (MPB70);
- and cell surface lipoprotein Mpb83 (MPB83) or a homologue, paralogue, orthologue, functional fragment or variant thereof.
Dependencies are inferred from the claim text.