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US 12,491,237 B2Granted
Vaccine compositions and methods for the treatment and prevention of urinary tract infections
AssigneeDuke University
InventorsSoman Abraham, Jianxuan Wu
Life of this patent
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Abstract
Disclosed herein are vaccine compositions for the treatment and prevention of urinary tract infections (UT!s) and methods for delivery of the vaccine compositions. Moreover, the disclosure provides adjuvant compositions for vaccines to modulate cellular responses, such as an immune response.
Claims29
A recombinant vaccine composition comprising:
- a truncated fimbrial protein, wherein the truncated fimbrial protein is SEQ ID NO:
- 4;
- and,
- an adjuvant that includes and stimulates a T helper cell 1 (Th1) response.
1 more element
A method of treating or preventing a urinary tract infection (UTI) in a subject comprising administering to the subject a recombinant vaccine composition comprising:
- a truncated fimbrial protein, wherein the truncated fimbrial protein is SEQ ID NO:
- 4;
- and,
- an adjuvant that includes and stimulates a T helper cell 1 (Th1) response;
- wherein the recombinant vaccine composition is administered locally to the bladder of the subject.
2 more elements
A method of preparing a recombinant vaccine composition comprising the steps of:
- (a) providing a truncated fimbrial protein, wherein the truncated fimbrial protein is SEQ ID NO:
- 4;
- and
- (b) combining the truncated fimbrial protein with an adjuvant that induces and stimulates a T helper cell 1 (Th1) response.
1 more element
Dependencies are inferred from the claim text.