Compositions containing indole-derived metabolites and methods of use thereof
AssigneeImvela Corp.
InventorsRaphaël Turcotte, Ravi Sheth, Jonna Heldrich, Corentin Moevus
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Abstract
Some aspects of the disclosure relate to compositions comprising fermentates of bacterial strains capable of producing indole-containing compounds such as ILA and IAld. Some aspects relate to nutritional supplements, and food products containing such fermentates, and methods of use thereof.
Claims14
A method of reducing itching severity in a subject in need thereof, the method comprising orally administering to the subject a nutritional supplement or food product comprising a bacterial fermentate mixture, the bacterial fermentate mixture comprising a first fermentate and a second fermentate of a bacterial strain comprising a 16S rDNA sequence with at least 97% sequence identity to the nucleotide sequence of SEQ ID NO:
- 1,
- wherein the first fermentate comprises more indole-3-lactic acid (ILA) than indole-3-carboxaldehyde (IAld) and the second fermentate comprises more IAld than the first fermentate,
- wherein:
- (i) the first fermentate is produced by incubating the bacterial strain under microaerobic conditions in a first fermentation medium comprising 1 g/L to 50 g/L tryptophan;
- and
- (ii) the second fermentate is produced by incubating the bacterial strain under aerobic conditions in a second fermentation medium comprising 1 g/L to 50 g/L tryptophan,
- wherein the bacterial fermentate mixture is substantially free of viable bacterial cells of the bacterial strain.
Dependencies are inferred from the claim text.