OTIC formulations, methods and devices

A method for treating an infection in an ear canal of a mammal, comprising applying a single dose of an otic formulation into the ear canal of a mammal with an ear infection, the otic formulation comprising:

• a) therapeutic agents consisting of:
• i) about 1.5% to 1.9% w/w of marbofloxacin;
• ii) about 1.6% to 3.3% w/w of terbinafine or salts thereof;
• and
• iii) about 0.1% to 0.3% w/w of dexamethasone;
• wherein the formulation further comprises,
• b) about 17% to 26% w/w of wax;
• and
• c) about 70% to 80% w/w of mineral oil.