US 12,491,145 B2 · Synthesis and purification of cannabigerol and its application

Abstract

The present invention relates to a method for producing cannabigerol and purifying it from a reaction mixture. The present invention also relates to the cosmetic use of cannabigerol for the inhibition of tyrosinase activity and/or the reduction of melanin production in the skin, in particular for reducing pigmentation of the skin, preferably for the improvement of the appearance of the skin in case of hyperpigmentation, lentigo or vitiligo. Furthermore, the present invention relates to cannabigerol for use in a therapeutic method for the inhibition of tyrosinase activity and/or the reduction of melanin production in the skin, preferably for use in a therapeutic method for the treatment and/or prevention of malign skin disorders, in particular skin cancer.

Claims8

Dependent claims

A method for producing cannabigerol, the method comprising:

(i) reacting olivetol with one or more allylic compound(s) having a leaving group in the presence of an acidic or Lewis acidic catalyst and forming cannabigerol, and wherein at least one of said allylic compound(s) is an allylic compound of formula (I) or (II), wherein X represents the leaving group;
and wherein the olivetol is reacted with said allylic compound(s) at a molar ratio of olivetol- to-the allylic compounds being in the range of from 1:1.2 to 1:1.9;
and (ii) purifying cannabigerol by distillation.

Dependencies are inferred from the claim text.

Synthesis and purification of cannabigerol and its application

Life of this patent

Synthesis and purification of cannabigerol and its application

Life of this patent

Abstract

Claims8