Device and method for taking up and handling a liquid sample and a substance

A device for taking up and handling a liquid sample and a substance having a sample unit and a substance container, in which

• the substance container has a reservoir that is configured to store the substance in the reservoir;
• the reservoir has an opening that is closed by a sealing film or a sealing plate so that the substance is sealed toward an environment in the reservoir;
• the sample unit has a sampler and an opener;
• the sampler is configured to take up and hold the liquid sample;
• the opener is configured to be at least partially introduced into the opening of the reservoir and to raise the sealing film or sealing plate from the opening, wherein a surface of the opener that is arranged in the direction of the sealing film or sealing plate and that is introduced into the opening and raises the sealing film or sealing plate from the opening is configured such that the surface is aligned at an oblique angle to the surface of the sealing film or sealing plate on contact with the sealing film or sealing plate and raises the sealing film or sealing plate successively from the opening on the introduction into the opening so that an outlet is formed in the sealing film or sealing plate through which the substance exits the reservoir and is miscible with the liquid sample of the sampler,
• wherein the opener is formed as a ring that is connected to the sampler via a first web extending downwardly from the ring, and a second web extending laterally from the first web to a jacket of the sample unit and downwardly to connect with the sampler.