Methods and devices for measuring structural and functional properties of tissue
AssigneeBioxytech Retina, Inc.
InventorAli Basiri
Life of this patent
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Abstract
Provided herein are methods and systems for determining a parameter across a surface of a tissue such as a retinal tissue of an eye of a subject. In some cases, the determined parameter is tissue oxygenation which can be used for a variety of clinical applications such as diagnosing and/or modeling a disease in the subject. In some examples, the method is performed by detecting one or more optical signals from the tissue using an optical detector, and processing the detected optical signals to characterize and map the parameter across the surface of the tissue. The methods and systems provided herein can prove accurate physics-based models of parameters such as tissue oxygenation across a heterogeneous tissue surface.
Claims17
A method of detecting a retinal disease of a tissue of an eye, the method comprising:
- (a) receiving from a detector reflected optical signals, wherein the reflected optical signals comprise at least a first reflected optical signal at a first wavelength range and a second reflected optical signal at a second wavelength range, wherein the first wavelength range and the second wavelength range are distinct, and wherein the reflected optical signals comprise a spatially varying component in at least one axis across a surface of the tissue of the eye;
- (b) normalizing the reflected optical signals to form normalized data, wherein the normalized data comprises a ratio of AC and DC components of the spatially varying component of the reflected optical signals at the first wavelength range and the second wavelength range across the surface of the tissue of the eye;
- and
- (c) determining at least one oxygenation parameter based on the normalized data, wherein the at least one oxygenation parameter comprises an analog of blood oxygenation of the tissue of the eye, wherein the at least one oxygenation parameter comprises a first oxygenation parameter determined at an optic disc of the eye and a second oxygenation parameter determined at one or more blood vessels of the eye away from the optic disc;
- wherein the retinal disease is detected in a response to a difference between the first oxygenation parameter at the optic disc and the second oxygenation parameter at the one or more blood vessels away from the optic disc.
A device to detect retinal disease of a tissue of an eye, the device comprising:
- an optical source comprising at least a first wavelength range and a second wavelength range, wherein the optical source is configured to project an optical pattern on a surface of the tissue of the eye, the optical pattern comprising a spatially varying component in at least one axis across the surface of the tissue of the eye;
- a detector to collect reflected optical signals comprising a first reflected optical signal from the first wavelength range and a second reflected optical signal from the second wavelength range, wherein the first and the second wavelength ranges are distinct;
- a processor operatively coupled to the detector, the processor comprising a non-transitory computer readable storage medium comprising instructions, the instructions configured to:
- normalize the reflected optical signals to form normalized data, wherein the normalized data comprises a ratio of AC and DC components of the spatially varying component of the reflected optical signals at the first wavelength range and the second wavelength range across the surface of the tissue of the eye;
- and
- determine at least one oxygenation parameter based on the normalized data, wherein the at least one oxygenation parameter comprises an analog of blood oxygenation saturation of the tissue of the eye, wherein the at least one oxygenation parameter comprises a first oxygenation parameter determined at an optic disc of the eye and a second oxygenation parameter determined at one or more blood vessels of the eye away from the optic disc;
- wherein the retinal disease is detected in a response to a difference between the first oxygenation parameter at the optic disc and the second oxygenation parameter at the one or more blood vessels away from the optic disc.
Dependencies are inferred from the claim text.