Microfabricated differential scanning calorimetry system and methods of use thereof
AssigneeUniversity of Louisville Research Foundation, Inc.
InventorsThomas J. Roussel, Jr., Nichola C. Garbett, Alexa M. Melvin
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Abstract
A differential scanning calorimetry sensor, comprises a substrate; a heater trace comprising a conductive material, on the substrate; an encapsulation layer, on the substrate and on the heater trace; and a sample heating area, which is on the heater trace. The heater trace has a thickness of 50 to 1000 nm, a width of 1 to 100 pm, and a path length of 5 to 500 mm. Also described are a sample holder, a sensor enclosure and a thermal analysis sensor system.
Claims18
A differential scanning calorimetry sensor, comprising:
- a substrate,
- a heater trace comprising a conductive material, on the substrate, and
- an encapsulation layer, on the substrate and on the heater trace,
- wherein the heater trace has a thickness of 50 to 1000 nm, a width of 1 to 100 μm, and a path length of 5 to 500 mm, and
- the differential scanning calorimetry sensor does not include a separate temperature sensor, and the heater trace is configured to function to both heat a sample and measure the temperature of the sample.
A thermal analysis sensor system, comprising:
- (a) a sensor enclosure, comprising:
- (i) an enclosure base,
- (ii) a first printed circuit board on the enclosure base,
- (iii) a differential scanning calorimetry sensor, on and electrically connected to the first printed circuit board, and
- (iv) an electrical connector electrically connected to the first printed circuit board, passing through the enclosure base, and
- (b) a sample holder, on the differential scanning calorimetry sensor, comprising:
- (A) a sample holder body having an external surface,
- (B) a sample chamber having a volume of 1 to 500 μL, inside the sample holder body, and
- (C) an inlet channel and an outlet channel, each fluidly connecting the sample chamber to the external surface of the sample holder body,
- wherein the sample holder body has an isolation membrane, separating the sample chamber from the external surface, and the isolation membrane has a thickness of at most 500 μm,
- the differential scanning calorimetry sensor comprises:
- (1) a substrate,
- (2) a heater trace comprising a conductive material, on the substrate, and
- (3) an encapsulation layer, on the substrate and on the heater trace, wherein the heater trace has a thickness of 50 to 1000 nm, a width of 1 to 100 μm, and a path length of 5 to 500 mm, and
- the differential scanning calorimetry sensor does not include a separate temperature sensor, and the heater trace is configured to both heat a sample in the sample chamber and measure the temperature of the sample in the sample chamber.
Dependencies are inferred from the claim text.