Particulate lyophilized platelet lysate compositions
AssigneeJadi Cell LLC
InventorAmit Patel
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Abstract
A particulate lyophilized platelet lysate composition suitable for use as a cell culture medium can include growth factors, cytokines, and chemokines released from lysis of source platelets, wherein cellular debris from the source platelets is removed (partially or fully) by filtration. The growth factors, cytokines, and chemokines are lyophilized to form a particulate lyophilized platelet lysate composition.
Claims26
A particulate lyophilized platelet lysate composition, comprising lysed platelets resulting from freeze-thaw lysis of source platelets, wherein the freeze-thaw lysis is carried out by at least two freeze-thaw cycles, wherein the lysed platelets are filtered to remove cellular debris at least in part after the freeze-thaw lysis followed by lyophilization to form the particulate lyophilized platelet lysate composition, wherein the particulate lyophilized platelet lysate composition includes a solids content of at least 70 wt % of growth factors, cytokines, and chemokines released from the freeze-thaw lysis of the source platelets.
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