Method for preparing controlled peptide-based polymers and copolymers in an aqueous solution
AssigneesUniversite De Bordeaux, Institut Polytechnique De Bordeaux, Centre National De La Recherche Scientifique
InventorsSébastien Lecommandoux, Colin Bonduelle, Elisabeth Garanger, Chloé Grazon
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Abstract
The present invention relates to a “one-pot” method for preparing an aqueous solution of nanoparticles with amphiphilic block copolymers and comprising polypeptide units, the method comprising at least one step (E1), in an aqueous solvent, consisting of bringing together: —at least one hydrophilic polymer (P1) comprising at least one amine function, and —at least one hydrophobic α-amino acid N-carboxyanhydride monomer.
Claims9
A one pot method for preparing an aqueous solution of nanoparticles of amphiphilic block copolymers and comprising polypeptide units, said method comprising at least one step (E1) in an aqueous solvent free of organic solvent, consisting of bringing together:
- at least one hydrophilic polymer (P1) comprising at least one amine function, and
- at least one hydrophobic α-amino acid N-carboxyanhydride monomer,
- wherein the polymer (P1) is chosen from polymers having the following formula:
- where x is from 16 to 500, and
- elastin-like polypeptides (ELPs) comprising at least one amine function.
Dependencies are inferred from the claim text.