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US 12,486,334 B2Granted
Chemically controlled monoclonal antibody target engagement
AssigneeThe Regents of the University of California
InventorsCharles S. Craik, Kevan M. Shokat, Ziyang Zhang, Peter J. Rohweder
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Abstract
The present disclosure relates generally to antibodies reactive with tumor-specific neoantigens, as well as neoantigen-binding fragments thereof. The present disclosure also relates to nucleic acids, expression cassettes, and expression vectors encoding the antibodies and neoantigen-binding fragments. The antibodies and neoantigen binding-fragments are useful for diagnosis and treatment of cancer.
Claims13
An antibody or antigen binding fragment thereof, comprising:
- (a) a light chain variable region comprising a CDRL1 of SEQ ID NO:33, a CDRL2 of SEQ ID NO:34, CDRL3 of SEQ ID NO:35, and a heavy chain variable region comprising a CDRH1 of SEQ ID NO:36, a CDRH2 of SEQ ID NO:37, and a CDRH3 of SEQ ID NO:38;
- (b) a light chain variable region comprising a CDRL1 of SEQ ID NO:25, a CDRL2 of SEQ ID NO:26, CDRL3 of SEQ ID NO:27, and a heavy chain variable region comprising a CDRH1 of SEQ ID NO:28, a CDRH2 of SEQ ID NO:29, and a CDRH3 of SEQ ID NO:30;
- (c) a light chain variable region comprising a CDRL1 of SEQ ID NO:17, a CDRL2 of SEQ ID NO:18, CDRL3 of SEQ ID NO:19, and a heavy chain variable region comprising a CDRH1 of SEQ ID NO:20, a CDRH2 of SEQ ID NO:21, and a CDRH3 of SEQ ID NO:22;
- (d) a light chain variable region comprising a CDRL1 of SEQ ID NO:41, a CDRL2 of SEQ ID NO:42, CDRL3 of SEQ ID NO:43, and a heavy chain variable region comprising a CDRH1 of SEQ ID NO:44, a CDRH2 of SEQ ID NO:45, and a CDRH3 of SEQ ID NO:46;
- or
- (e) a light chain variable region comprising a CDRL1 of SEQ ID NO:49, a CDRL2 of SEQ ID NO:50, CDRL3 of SEQ ID NO:51, and a heavy chain variable region comprising a CDRH1 of SEQ ID NO:52, a CDRH2 of SEQ ID NO:53, and a CDRH3 of SEQ ID NO:54, and
- wherein the antibody or antigen binding fragment binds to an antigen comprising the amino acid sequence GAC (1620) GVGKSAL (SEQ ID NO:2) but not the amino acid sequence GACGVGKSAL (SEQ ID NO:1), wherein 1620 is ARS-1620.
4 more elements
Dependencies are inferred from the claim text.