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US 12,486,322 B2Granted
Anti-complement factor C1q antibodies with single binding arms and uses thereof
AssigneeAnnexon, Inc.
InventorsTed Yednock, Sethu Sankaranarayanan
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Abstract
The present disclosure relates generally to antibodies with a single antigen-binding arm comprising a single antigen-binding arm and an Fc region such as a single-arm antibodies. The present disclosure also relates generally to the use of such antibodies such as treating a disease associated with complement activation.
Claims12
An antibody that binds to C1q, comprising a single C1q antigen-binding arm and an Fc region, wherein the antibody comprises:
- i) a light chain, wherein:
- the amino acid sequence of the light chain comprises an amino acid sequence with at least about 85% homology to the amino acid sequence of SEQ ID NO:
- 1 and wherein the light chain comprises an HVR-L1 having the amino acid sequence of SEQ ID NO:
- 4, an HVR-L2 having the amino acid of SEQ ID NO:
- 5, and an HVR-L3 having the amino acid of SEQ ID NO:
- 6;
- ii) a first and a second heavy chain, wherein:
- the amino acid sequence of the first heavy chain comprises the amino acid sequence of SEQ ID NO:
- 2;
- and
- the amino acid sequence of the second heavy chain consists of the amino acid sequence of SEQ ID NO:
- 3.
9 more elements
Dependencies are inferred from the claim text.