Peptide ligand targeting carbonic anhydrase IX, peptide construct comprising same, and uses thereof

A CAIX-specific peptide construct comprising a peptide ligand consisting of any one of amino acid sequence selected from the group consisting of SEQ ID NOs:

• 1 to 44, wherein at least one of the constituent amino acids is composed of D-amino acids and a lysine (Lys) residue among the constituent amino acids may be substituted with a chemical functional group at the side chain ε-amino group;
• and
• a sulfonamide functional group-containing amino acid residue linked to the peptide ligand directly or through a spacer;
• wherein the peptide construct has a cyclic structure represented by Formula 1 below:
• wherein,
• P is the peptide ligand,
• F1 is a glycine (Gly) or a sulfonamide functional group-containing amino acid residue,
• F2 is a sulfonamide functional group-containing amino acid residue,
• F3 is a glycine (Gly) or a functional group-containing amino acid residue other than sulfonamide,
• n and m are each independently 0 or 1,
• F4 is a group of the general formula —(S1)o—(F5)p—(S2)q—(F6)r—NH2, wherein
• S1 and S2 are each independently a spacer,
• F5 and F6 are each independently a functional group-containing amino acid residue other than sulfonamide,
• wherein the functional group other than sulfonamide is chelator, cycloalkane having 5 to 15 carbon atoms, biotin, glucoheptonic acid, 4-(p-iodophenyl) butyric acid (IB), fluorescent dye, or cytotoxic agent, and
• o, p, q and r each independently represent an integer of 0 to 6.