Use of peptide for inhibiting functions and expressions of multiple disease biomarkers

Abstract

The present invention relates to a novel use of a peptide for inhibiting the functions and expressions of multiple disease biomarkers, and more specifically, to a pharmaceutical composition for treating or preventing inflammation, metabolic diseases or fibrotic diseases, the composition comprising any one or more peptide among peptides which are represented by the amino acid sequences of SEQ ID NOs: 1 to 8 have the functions of inhibiting HDAC5 phosphorylation, the expression of the GDF15 protein, and the expression of the ATF3 protein. The peptide, according to the present invention, enables the triple-blocking of the biomarkers associated with inflammation, metabolic diseases or fibrotic diseases by inhibiting HDAC phosphorylation, inhibiting the expression of the GDF15 protein and inhibiting the expression of the ATF3 protein, and thus the production of inflammatory cytokine may be reduced, and thus the peptide is effective in preventing and treating inflammatory, metabolic or fibrotic diseases.

Dependencies are inferred from the claim text.