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US 12,486,300 B2Granted
Mithramycin oxime derivatives having increased selectivity and anti-cancer activity
AssigneeUniversity of Kentucky Research Foundation
InventorsJon S. Thorson, Jurgen Rohr, Markos Leggas, Joseph M. Eckenrode, Yinan Zhang, Yang Liu, Jianjun Zhang, Khaled Attia Shaaban Mahmoud
Life of this patent
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Abstract
Compounds described herein are mithramycin (MTM) oxide (OX) derivatives. These compounds are useful for treatment of cancers and neuro-diseases.
Claims12
A compound having the following formula:
- or a pharmaceutically acceptable salt thereof, wherein R is selected from the group consisting of substituted or unsubstituted amino acid, amino acid dipeptide, acyl-amino acid, and acyl-amino acid dipeptide.
Dependencies are inferred from the claim text.