Back to results
US 12,486,292 B2Granted
Prodrug platform useful to deliver amines, amides and phenols
AssigneeChangchun Changcheng Pharmaceutical Technology Co., LTD
InventorMingyan Xu
Life of this patent
Estimating the term…
Abstract
A prodrug platform is useful to deliver pharmaceutically active amines, amides and phenols and their use in the diagnosis, prevention and/or treatment of various diseases. Compared with the parent drug (e.g., Gemcitabine), the prodrugs show a significant overall safety improvement (therapeutic index (TI) improvement), especially in liver. The prodrugs can treat several diseases, including, for example, cancer, metabolic disease, viral infection, immunological disease, neurologic disease, and blood disease.
Claims20
A compound having formula (I):
- its stereoisomer, salt, hydrate, solvate, or crystalline form thereof;
- wherein,
- Ar is independently selected from the group consisting of optionally substituted aryl and heteroaryl;
- X is —NR′—;
- R′ is independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted aryl, and optionally substituted heteroaryl;
- and
- Q is a group that H-X-Q together represents a pharmaceutically active agent or prodrug thereof, and the pharmaceutically active agent is a chemical compound having at least one free aromatic amine or amide group,
- wherein H—X-Q together represents one selected from the group consisting of gemcitabine, tenofovir disoproxil, pamiparib, talazoparib, olaprib, veliparib, HY-14478, pioglitazone, lenvatinib, HY-103039, OS-9620, HY-103665, HY-123943, grapiprant, HY-10413, HY-50901, HY-10797, HY-103088, and apatinib.
5 more elements
Dependencies are inferred from the claim text.