Crystalline salt of eribulin
AssigneeYonsung Fine Chemical Co., Ltd.
InventorsAreum Baek, Hyunik Shin, Yongseo Park, Seongtaek Kim, Seunghui Sin
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Abstract
An eribulin salt formed by combining an eribulin free base with a low molecular weight amine compound through a diacid compound is disclosed. As the diacid compound, edisylic acid, 1,5-naphthalenedisulfonic acid, trans-2-butene-1,4-dicarboxylic acid, pyrophosphoric acid, and combination thereof may be employed. As the amine, ammonia, cyclohexylamine, dicyclohexylamine, and a combination thereof may be employed. The eribulin salt can be crystallized by recrystallization to produce a crystalline eribulin salt with increased purity.
Claims14
An eribulin salt represented by the following formula (I):
- wherein,
- Y represents a diacid compound, and
- Z represents an amine compound, wherein the diacid compound is selected from the group consisting of edisylic acid, 1,5-naphthalenedisulfonic acid, trans-2-butene-1,4-dicarboxylic acid and pyrophosphoric acid and wherein the amine compound is selected from the group consisting of ammonia, cyclohexylamine and dicyclohexylamine.
Dependencies are inferred from the claim text.