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US 12,486,271 B2Granted
Solid forms of a toll-like receptor modulator
AssigneeGilead Sciences, Inc.
InventorsBrandon Heath Brown, Paul A. Roethle
Life of this patent
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Abstract
The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
Claims20
A method of treating HIV in a human in need thereof, the method comprising administering to the human a therapeutically effective amount of a crystalline form of Compound I having the structure:
- characterized by an X-ray powder diffraction (XRPD) pattern comprising peaks at 5.8, 11.6, and 22.3 degrees 2θ (±0.2 degrees 2θ), wherein the XRPD is made using CuKα1 radiation.
A method of treating HIV in a human in need thereof, the method comprising administering to the human a pharmaceutical composition comprising a therapeutically effective amount of a crystalline form of Compound I having the structure:
- characterized by an X-ray powder diffraction (XRPD) pattern comprising peaks at 5.8, 11.6, and 22.3 degrees 2θ (±0.2 degrees 2θ), wherein the XRPD is made using CuKα1 radiation;
- and
- a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.