Targeted nitroxide compounds and their use in treating ferroptosis-related diseases
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsPeter Wipf, Taber Sarah Maskrey, Matthew G. LaPorte, Manwika Charaschanya
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Abstract
Provided herein are compounds useful in the prevention or treatment of ferroptosis in a patient, and methods of preventing or treating ferroptosis, or a treating a condition or disease associated with ferroptosis, such as a patient having a neurodegenerative disease, traumatic brain injury, acute kidney disease, liver injury, ischemia/reperfusion injury, ischemic stroke, intracerebral hemorrhage, liver fibrosis, diabetes, acute myeloid leukemia, age-related macular degeneration, psoriasis, a hemolytic disorder, or an inflammatory disease.
Claims16
A compound having the structure:
- wherein,
- R8 is an acyl group;
- R10 is (C1-C6)alkyl or (C3-C8)cycloalkyl, optionally substituted with, independently, 1, 2, or 3 F atoms;
- R11 is H;
- R12 and R13 are, independently, (C1-C6)alkyl or (C3-C8) cycloalkyl, that is optionally substituted with 1, 2, or 3 F atoms, or R12 and R13 together form a cycloalkyl ring or a heterocycloalkyl ring comprising one O, S, or N atom;
- R14 is optionally substituted —NH—R15, wherein R15 is a nitroxide -containing group;
- and
- the double bond is cis or trans configured,
- or a pharmaceutically-acceptable salt thereof, including stereoisomers thereof and mixtures of stereoisomers thereof.
Dependencies are inferred from the claim text.