N-substituted indoles and use as allosteric modulators of cannabinoid receptors

A compound having a structure according to Formula I

• wherein
• X and Y are CH;
• Z is (CH2)k, and k is 0 to 4;
• A is an unsaturated carbocyclic ring and n is 2;
• B is phenyl or a 5 to 6 membered heteroaryl ring;
• R1 is H, OH, ═CH2, or C1 to C5 alkyl, linear or branched, optionally substituted with CO2H, CONH2, or —C═C—;
• R2 is H, halogen, or alkyl;
• R4 is H, halogen, alkoxy, OH, alkyl, haloalkyl, optionally substituted, alkyne, NO2, CN, CO2R, NR2, a deuterated alkyl group, a five- or six-membered heterocyclic ring, a (hetero)aromatic ring, or SO2NHR, wherein R is independently H or alkyl, optionally substituted;
• R3 is H;
• R5 is H;
• R6 is CO2H;
• (CHR7)pCO2R7;
• CN;
• CONH2;
• alkoxy;
• CONR7R8;
• aryl;
• heterocyclic ring;
• CH═CHCO2R7;
• or (CHR7)yCOR7;
• wherein R7 and R8, including each of R7, is independently H or alkyl, optionally substituted, p is 2 to 4 and y is 0 to 4;
• * represents a chiral center;
• and
• m is 0 to 5, with the proviso that, when m=0, R1 and R6 are bonded to the atom marked with *.