Rosmarinic acid derivative, Rosmarinic acid-derived particles, composition containing same for treating inflammatory disease
AssigneeKorea Advanced Institute of Science and Technology
InventorsSang Yong Jon, Chan Ho Chung, Wonsik Jung, Afia Tasnim Rahman
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Abstract
The present disclosure relates to a rosmarinic acid derivative, rosmarinic acid-derived particles, and a composition containing same for treating an inflammatory disease. The use of the rosmarinic acid derivative and rosmarinic acid-derived particles of the present disclosure enables the utilization of rosmarinic acid, which has been restricted in the utilization thereof due to low water solubility and low bioavailability, for a medicinal purpose.
Claims2
A method for treating inflammatory disease, comprising administering a pharmaceutical composition to a subject in need thereof,
- wherein the inflammatory disease is inflammatory bowel disease (IBD) or colitis,
- wherein the pharmaceutical composition comprises microparticles comprising a rosmarinic acid derivative and a pharmaceutically acceptable carrier,
- wherein the rosmarinic acid derivative is represented by the following chemical formula:
- wherein —X is a (Y—Z), and
- i) —Y— is —NH—, and —Z is methoxy polyethyleneglycol (mPEG) residue,
- ii) —Y is —NH—, and —Z is hyaluronic acid residue, or
- iii) —Y— is —NH—, and —Z is chitosan residue.
Dependencies are inferred from the claim text.